Anodal tDCS Enhances Verbal Episodic Memory in Initially Low Performers.
Anodal tDCS Enhances Verbal Episodic Memory in Initially Low Performers.
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DOI：
10.3389/fnhum.2017.00542
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发表时间：
2017
影响因子：
2.9
通讯作者：
Peter J
中科院分区：
文献类型：
--
作者：
Habich A;Klöppel S;Abdulkadir A;Scheller E;Nissen C;Peter J
左背外侧前额叶皮层（DLPFC）参与情景记忆的编码和检索，因此，经常成为非侵入性脑刺激范例的目标，旨在实现其功能调节。阳极经颅直流电刺激 (tDCS) 可提高受刺激皮质区域的神经元兴奋性，已发现可以根据初始表现不同地提高认知技能。我们假设 tDCS 对言语情景记忆的益处可以从参与者的基线表现推断出来。在目前的随机、双盲、平行组研究中，健康的年轻人 (n = 43) 在言语情景记忆任务的编码阶段接受了对左侧 DLPFC 的真实阳极或假 tDCS。四十个单词在视觉上呈现三次，每个块后立即进行声音检索，并进行额外的延迟回忆。我们进行了调节分析，以测试初始情景记忆检索的调节效果，并根据首要效应和近因效应进行调整，对真实或虚假刺激下的延迟回忆进行调整。尽管在群体层面上没有显着有益的 tDCS 效果，但我们发现，第一次检索中记住的中间列表单词的数量显着调节了刺激效果，使得最初表现不佳的人从真实刺激中获得了最高的收益。这些结果表明，左侧 DLPFC 的阳极 tDCS 只能改善记忆功能。虽然在认知未受损的人群中只有边际刺激引起的增益发生，但在言语情景记忆领域具有临床相关缺陷的个体中可能会出现更大的刺激益处。
The left dorsolateral prefrontal cortex (DLPFC) is involved in encoding and retrieval of episodic memories, and thus, is frequently targeted in non-invasive brain stimulation paradigms, aiming for its functional modulation. Anodal transcranial direct current stimulation (tDCS), that boosts neuronal excitability in stimulated cortical areas, has been found to increase cognitive skills differentially, depending on the initial performance. We hypothesize that the benefit of tDCS on verbal episodic memory can be extrapolated from the participants’ baseline performance. In the present randomized, double-blind, parallel group study, healthy young adults (n = 43) received either real anodal or sham tDCS over their left DLPFC during the encoding phase of a verbal episodic memory task. Forty words were presented visually thrice with immediate vocal retrieval after each block and an additional delayed recall. We conducted a moderation analysis to test the modulating effect of initial episodic memory retrieval, adjusted for primacy and recency effects, on delayed recall under real or sham stimulation. Despite the absence of a significantly beneficial tDCS effect at the group level, we found that the number of remembered midlist words in the first retrieval significantly moderated the stimulation effect in such a way that initially low performers experienced the highest gain from real stimulation. These results suggest that anodal tDCS to the left DLPFC improves memory functions only so far. While only marginal stimulation-induced gains occur in cognitively unimpaired populations, greater stimulation benefits might be expected in individuals with clinically relevant deficiencies in the verbal episodic memory domain.
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