Deliberation and Commitment in the Premotor and Primary Motor Cortex during Dynamic Decision Making
Deliberation and Commitment in the Premotor and Primary Motor Cortex during Dynamic Decision Making
复制标题
动态决策过程中运动前皮层和初级运动皮层的深思熟虑和承诺
DOI：
10.1016/j.neuron.2014.01.031
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发表时间：
2014
期刊：
影响因子：
16.2
通讯作者：
P. Cisek
中科院分区：
文献类型：
--
作者：
David Thura;P. Cisek
关于决策的神经生理学研究主要集中在关于随着时间推移而稳定的信息的决策上。然而，在自然行为中，动物在不断变化的环境中做出决定。为了探索这种动态选择的神经机制，我们记录了猴子在背侧前运动区(PMD)和初级运动皮质(M1)的活动，同时猴子执行了一项两项选择到达任务，其中关于正确选择的感觉信息在每次实验中都会发生变化，并且可以在任何时候做出决定。在深思熟虑期间，这两个区域的活动没有整合感觉信息，而是跟踪它，并将其与日益增长的紧急信号结合在一起。在运动开始前约280ms，调谐到所选目标的PMD活动达到一致的峰值，而调谐到未选择目标的M1活动被抑制。我们认为，这反映了潜在反应之间竞争的解决，并构成了对行动选择的自愿承诺。
Neurophysiological studies of decision making have primarily focused on decisions about information that is stable over time. However, during natural behavior, animals make decisions in a constantly changing environment. To investigate the neural mechanisms of such dynamic choices, we recorded activity in dorsal premotor (PMd) and primary motor cortex (M1) while monkeys performed a two-choice reaching task in which sensory information about the correct choice was changing within each trial and the decision could be made at any time. During deliberation, activity in both areas did not integrate sensory information but instead tracked it and combined it with a growing urgency signal. Approximately 280 ms before movement onset, PMd activity tuned to the selected target reached a consistent peak while M1 activity tuned to the unselected target was suppressed. We propose that this reflects the resolution of a competition between the potential responses and constitutes the volitional commitment to an action choice.
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