Exposure to PBDEs in the office environment: evaluating the relationships between dust, handwipes, and serum.
Exposure to PBDEs in the office environment: evaluating the relationships between dust, handwipes, and serum.
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DOI：
10.1289/ehp.1003271
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发表时间：
2011-09
影响因子：
10.4
通讯作者：
Webster TF
中科院分区：
文献类型：
--
作者：
Watkins DJ;McClean MD;Fraser AJ;Weinberg J;Stapleton HM;Sjödin A;Webster TF
背景：多溴二苯醚（PBDE）已广泛用作消费品中的阻燃剂，并且在住宅室内空气和灰尘中普遍存在。然而，人们对办公室环境中的暴露知之甚少。目的：我们通过同时测量血清、手巾和办公室灰尘中的 PBDE，研究了办公室环境中 PBDE 浓度与内部暴露之间的关系。方法：我们从 31 名每周在办公室工作至少 20 小时的参与者那里收集了血清、灰尘和手巾样本。我们使用问卷来收集有关工作和个人习惯的信息。结果：我们发现室内灰尘、手巾（个人暴露量的衡量标准）和血清中的 PBDE 之间存在正相关。办公室灰尘中的 PBDE 浓度与手巾中的测量值呈弱相关：五溴二苯醚（BDE 同系物 28/33、47、99、100 和 153 之和）的 r = 0.35 (p = 0.06)，BDE-209 的 r = 0.33 (p = 0.07)。洗手还可以预测手巾中的五溴二苯醚含量：洗手液中五溴二苯醚含量较低的人的手巾中五溴二苯醚含量是洗手液中含量高的人的 3.3 倍 (p = 0.02)。手巾中的五溴二苯醚可预测血清中的五溴二苯醚水平 (p = 0.03)：最高手巾三分位数中的血清浓度平均是最低手巾三分位数中的 3.5 倍。血清中五溴二苯醚的几何平均浓度为 27 纳克/克脂质。我们在 20% 的血清样本中检测到了 BDE-209，其含量范围为 < 4.8 至 9.7 ng/g 脂质。结论：我们的研究表明，在办公室环境中接触五溴二苯醚会增加五溴二苯醚的身体负担，而接触可能与手上的多溴二苯醚残留有关。此外，洗手可能会减少对多溴联苯醚的接触。
Background: Polybrominated diphenyl ethers (PBDEs) have been widely used as flame retardants in consumer products and are ubiquitous in residential indoor air and dust. However, little is known about exposure in the office environment. Objectives: We examined relationships between PBDE concentrations in the office environment and internal exposure using concurrent measurements of PBDEs in serum, handwipes, and office dust. Methods: We collected serum, dust, and handwipe samples from 31 participants who spent at least 20 hr/week in an office. We used a questionnaire to collect information about work and personal habits. Results: We found positive associations between PBDEs in room dust, handwipes (a measure of personal exposure), and serum. PBDE office dust concentrations were weakly correlated with measurements in handwipes: r = 0.35 (p = 0.06) for pentaBDE (sum of BDE congeners 28/33, 47, 99, 100, and 153) and 0.33 (p = 0.07) for BDE-209. Hand washing also predicted pentaBDE levels in handwipes: low hand-washers had 3.3 times the pentaBDE levels in their handwipes than did high hand-washers (p = 0.02). PentaBDE in handwipes predicted pentaBDE levels in serum (p = 0.03): Serum concentrations in the highest handwipe tertile were on average 3.5 times the lowest handwipe tertile. The geometric mean concentration of pentaBDEs in serum was 27 ng/g lipid. We detected BDE-209 in 20% of serum samples, at levels ranging from < 4.8 to 9.7 ng/g lipid. Conclusion: Our research suggests that exposure to pentaBDE in the office environment contributes to pentaBDE body burden, with exposure likely linked to PBDE residues on hands. In addition, hand washing may decrease exposure to PBDEs.
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影响因子：
10.4
作者：
Herbstman JB;Sjödin A;Kurzon M;Lederman SA;Jones RS;Rauh V;Needham LL;Tang D;Niedzwiecki M;Wang RY;Perera F
通讯作者：
Perera F
影响因子：
11.4
作者：
Johnson, Paula I.;Stapleton, Heather M.;Slodin, Andreas;Meeker, John D.
通讯作者：
Meeker, John D.
中国中南部室内灰尘中的多溴联苯醚：特征和影响。
影响因子：
8.8
作者：
Huang, Yumei;Chen, Laiguo;Ye, Zhixiang
通讯作者：
Ye, Zhixiang
溴化阻燃剂：值得关注吗？
影响因子：
10.4
作者：
Birnbaum LS;Staskal DF
通讯作者：
Staskal DF
影响因子：
10.4
作者：
Harley KG;Marks AR;Chevrier J;Bradman A;Sjödin A;Eskenazi B
通讯作者：
Eskenazi B