The medial dorsal thalamic nucleus and the medial prefrontal cortex of the rat function together to support associative recognition and recency but not item recognition.
The medial dorsal thalamic nucleus and the medial prefrontal cortex of the rat function together to support associative recognition and recency but not item recognition.
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DOI：
10.1101/lm.028266.112
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发表时间：
2012-12-21
期刊：
影响因子：
--
通讯作者：
Warburton EC
中科院分区：
文献类型：
--
作者：
Cross L;Brown MW;Aggleton JP;Warburton EC
在人类识别记忆缺陷，间脑性遗忘症的一个典型特征，已被暂时联系到丘脑背内侧核（MD）的损害。动物研究偶尔会调查MD在单个项目识别中的作用，但没有系统地分析它在其他识别记忆过程中的作用。在实验1中，在MD或内侧前额叶皮层（mPFC）的双侧兴奋性毒性病变的大鼠进行了测试的任务，评估单一项目的识别（新的对象偏好），联想识别记忆（对象的地方），和近因歧视（近因记忆任务）。实验2探讨了功能的重要性，MD和mPFC之间的相互作用，使用断开技术。在同一半球（MD + mPFC Ipsi）或对侧半球（MD + mPFC Contra组）的MD和mPFC中放置单侧兴奋性毒性损伤。双侧病变的MD或mPFC受损的对象在的位置和近因记忆任务，但没有影响新的对象偏好。在实验2中，与MD + mPFC Ipsi组相比，MD + mPFC Contra组在物体就位和近因记忆任务中显着受损，但新物体偏好完好无损。因此，MD和mPFC之间的连接是至关重要的识别记忆时，歧视涉及关联或近因信息。然而，啮齿类动物的MD是不必要的单一项目识别记忆。
In humans recognition memory deficits, a typical feature of diencephalic amnesia, have been tentatively linked to mediodorsal thalamic nucleus (MD) damage. Animal studies have occasionally investigated the role of the MD in single-item recognition, but have not systematically analyzed its involvement in other recognition memory processes. In Experiment 1 rats with bilateral excitotoxic lesions in the MD or the medial prefrontal cortex (mPFC) were tested in tasks that assessed single-item recognition (novel object preference), associative recognition memory (object-in-place), and recency discrimination (recency memory task). Experiment 2 examined the functional importance of the interactions between the MD and mPFC using disconnection techniques. Unilateral excitotoxic lesions were placed in both the MD and the mPFC in either the same (MD + mPFC Ipsi) or opposite hemispheres (MD + mPFC Contra group). Bilateral lesions in the MD or mPFC impaired object-in-place and recency memory tasks, but had no effect on novel object preference. In Experiment 2 the MD + mPFC Contra group was significantly impaired in the object-in-place and recency memory tasks compared with the MD + mPFC Ipsi group, but novel object preference was intact. Thus, connections between the MD and mPFC are critical for recognition memory when the discriminations involve associative or recency information. However, the rodent MD is not necessary for single-item recognition memory.
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影响因子：
3.4
作者：
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