Telomere shortening in the esophagus of Japanese alcoholics: relationships with chromoendoscopic findings, ALDH2 and ADH1B genotypes and smoking history.
Telomere shortening in the esophagus of Japanese alcoholics: relationships with chromoendoscopic findings, ALDH2 and ADH1B genotypes and smoking history.
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DOI：
10.1371/journal.pone.0063860
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Takubo K
中科院分区：
文献类型：
--
作者：
Aida J;Yokoyama A;Shimomura N;Nakamura K;Ishikawa N;Terai M;Poon S;Matsuura M;Fujiwara M;Sawabe M;Arai T;Takubo K
Lugol碘染色染色内镜为鳞状细胞癌（SCC）的发展提供了重要信息。特别是，明显大于10毫米的无碘染色病变（DIULs）在高级别上皮内瘤变中发病率很高。也有报道称，ALDH2*1/*2失活和ADH1B*1/*1失活以及吸烟是食管SCC的危险因素。我们之前研究了嗜酒者食管上皮的端粒缩短，并提示在这些个体中染色体不稳定的患病率很高。在本研究中，我们试图分析52例diul的端粒长度，参考它们的大小和多样性、ALDH2和ADH1B基因型以及吸烟史。DIULs <10 mm的患者（n = 42）端粒明显长于DIULs≥10 mm的患者（n = 10, p = 0.008）。端粒长度在ALDH2和ADH1B基因型（ALDH2活性/非活性= 35/17，ADH1B活性/非活性= 32/20,p = 0.563, 0.784）和根据吸烟史划分的四组（从不吸烟、戒烟、轻度吸烟、重度吸烟分别= 3、6、21、22例，p = 0.956）之间均无显著差异。无多个DIULs患者（n = 17）的端粒明显长于多个DIULs患者（n = 35, p = 0.040）。这表明酒精会减少食道端粒长度，与基因型或吸烟习惯无关。端粒缩短可能不会直接导致癌症，但可能会创造条件，使SCC更容易发展，这取决于随后接触致癌物。
Chromoendoscopy with Lugol iodine staining provides important information on the development of squamous cell carcinoma (SCC). In particular, distinct iodine-unstained lesions (DIULs) larger than 10 mm show a high prevalence in high-grade intraepithelial neoplasia. It has also been reported that inactive ALDH2*1/*2 and less-active ADH1B*1/*1, and smoking, are risk factors for esophageal SCC. We previously examined telomere shortening in the esophageal epithelium of alcoholics, and suggested a high prevalence of chromosomal instability in such individuals. In the present study, we attempted to analyze telomere lengths in 52 DIULs with reference to both their size and multiplicity, ALDH2 and ADH1B genotypes, and smoking history. Patients with DIULs <10 mm (n = 42) had significantly longer telomeres than those with DIULs ≥10 mm (n = 10, p = 0.008). No significant differences in telomere length were recognized between the ALDH2 and ADH1B genotypes (ALDH2 active/inactive = 35/17, ADH1B active/inactive = 32/20; p = 0.563, 0.784, respectively) or among four groups of patients divided according to smoking history (never-, ex-, light, and heavy smokers = 3, 6, 21, and 22 patients, respectively; p = 0.956). Patients without multiple DIULs (n = 17) had significantly longer telomeres than patients with multiple DIULs (n = 35, p = 0.040). It is suggested that alcoholism reduces telomere length in the esophagus, irrespective of genotype or smoking habit. Telomere shortening may not generate cancer directly, but may create conditions under which SCC can develop more easily, depending on subsequent exposure to carcinogens.
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影响因子：
3.7
作者：
Ma H;Zhou Z;Wei S;Liu Z;Pooley KA;Dunning AM;Svenson U;Roos G;Hosgood HD 3rd;Shen M;Wei Q
通讯作者：
Wei Q
影响因子：
3.3
作者：
Aida, Junko;Izumiyama-Shimomura, Naotaka;Takubo, Kaiyo
通讯作者：
Takubo, Kaiyo
影响因子：
3.9
作者：
Takubo, K;Izumiyama-Shimomura, N;Nakamura, KI
通讯作者：
Nakamura, KI
影响因子：
4.7
作者：
Asakage, Takahiro;Yokoyama, Akira;Watanabe, Hiroshi
通讯作者：
Watanabe, Hiroshi
影响因子：
6.4
作者：
Pavanello, Sofia;Hoxha, Mirjam;Dioni, Laura;Bertazzi, Pier Alberto;Snenghi, Rossella;Nalesso, Alessandro;Ferrara, Santo Davide;Montisci, Massimo;Baccarelli, Andrea
通讯作者：
Baccarelli, Andrea