Interleukin-10: a multi-faceted agent of pregnancy.
Interleukin-10: a multi-faceted agent of pregnancy.
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DOI：
10.1111/j.1600-0897.2010.00810.x
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发表时间：
2010-06
期刊：
影响因子：
--
通讯作者：
Sharma S
中科院分区：
文献类型：
--
作者：
Thaxton JE;Sharma S
人们普遍认为怀孕是一个独特的发育事件。前所未有的血管生成，免疫和神经内分泌调节的宫内行动并列的衰老机制，使胎儿的生长和保护。促进健康怀孕的抑制和调节因素正在调查中。在感染和炎症的非妊娠系统中，细胞因子白细胞介素-10（IL-10）由于其作为响应多种炎症事件的关键免疫抑制剂的潜力而被广泛研究。在妊娠的背景下，IL-10水平在妊娠早期显著增加，并在分娩开始前的第三个三个月保持升高。IL-10在妊娠期间作为母体主动免疫的抑制剂以允许接受胎儿同种异体移植物的作用一直是研究的重点。此外，已经证明，由不同的母体和胎儿细胞分泌IL-10有助于协调正常的妊娠过程。有趣的是，关于IL-10在妊娠期间的作用的一些更深刻的发现已经从关注由于炎症，激素失衡或基因-环境相互作用导致的异常妊娠结局的研究中得到了证实。本文综述了IL-10作为一种免疫抑制剂和胎盘与蜕膜间相互作用的调节剂在成功妊娠中的作用。重要的是，我们利用对不良妊娠条件的调查，进一步阐明IL-10在母胎界面的多种作用。
It is widely accepted that pregnancy constitutes a unique developmental event. Unprecedented intrauterine actions of angiogenesis, immunity, and neuroendocrine regulation are juxtaposed to mechanisms of senescence that enable fetal growth and protection. The suppressive and regulatory factors that facilitate healthy pregnancy are under investigation. In non-pregnant systems of infection and inflammation the cytokine interleukin-10 (IL-10) has been widely investigated due to its potential as a key immunosuppressant in response to a multitude of inflammatory events. In the context of pregnancy, IL-10 levels increase markedly in women during early pregnancy and remain elevated well into the third trimester immediately prior to onset of labor. The role of IL-10 during pregnancy as a suppressor of active maternal immunity to allow acceptance of the fetal allograft has been a point of study. Moreover, secretion of IL-10 by a diverse set of maternal and fetal cells has proven to aid in the orchestration of normal processes of pregnancy. Interestingly, some of the more profound findings regarding the actions of IL-10 during pregnancy have manifested from research that focuses on aberrant pregnancy outcomes as a result of inflammation, hormonal imbalances, or gene-environment interactions. This review focuses on the role of IL-10 as a facilitator of successful pregnancy both as an immune suppressive agent and mediator of cross-talk between the placenta and the decidua. Importantly, we utilize investigations into adverse pregnancy conditions to further elucidate the multifarious role of IL-10 at the maternal-fetal interface.
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