Aberrant functional connectivity of neural circuits associated with social and sensorimotor deficits in young children with autism spectrum disorder.
Aberrant functional connectivity of neural circuits associated with social and sensorimotor deficits in young children with autism spectrum disorder.
复制标题
与自闭症谱系障碍幼儿社交和感觉运动缺陷相关的神经回路功能连接异常
DOI：
10.1002/aur.2029
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发表时间：
2018-12
期刊：
影响因子：
--
通讯作者：
Chen H
中科院分区：
文献类型：
--
作者：
Chen H;Wang J;Uddin LQ;Wang X;Guo X;Lu F;Duan X;Wu L;Chen H
自闭症谱系障碍（ASD）是一种以脑区非典型功能整合为特征的神经发育障碍。绝大多数ASD的神经影像学研究都集中在年龄较大的儿童，青少年和患有这种疾病的成年人。很少有研究探索ASD幼儿的全脑功能连接。在这里，我们收集了58名幼儿（平均年龄4.98岁; 29名ASD患者; 29名匹配的健康对照（HC））的静息状态功能磁共振成像数据。所有儿童在扫描期间均处于镇静状态。一种功能性“连通性”方法首先被用来寻找ASD儿童中显示非典型功能性连通性（FC）的大脑区域。然后应用循环寻找策略揭示ASD儿童的非典型FC回路。ASD和HC之间的感兴趣区域（ROI）之间的FC矩阵进行了比较。最后，采用支持向量回归（SVR）方法评估FC回路与ASD症状严重程度之间的关系。两个非典型的FC电路，包括23个感兴趣区的ASD被发现：一个主要包括涉及社会认知的大脑区域，显示在ASD的连接不足;另一个主要包括感觉运动和视觉的大脑区域，显示在ASD的过度连接。SVR分析表明，这两个FC回路分别与社交缺陷和限制行为得分相关。这些研究结果表明，在ASD的幼儿参与社会和感觉运动过程的神经回路中断FC。在ASD幼儿中发现非典型FC模式强调了研究患有该疾病的幼儿的实用性，并突出了接近疾病发作的行为背后的大脑连接的细微差别模式。自闭症谱系障碍（ASD）是一种早发性神经发育障碍。了解早期脑功能改变对于理解ASD的生物学机制非常重要。在这里，我们发现了两个非典型的大脑功能回路的幼儿与ASD的社会和感觉运动功能。这些结果表明，ASD幼儿的大脑功能连接的非典型模式可能是该疾病的核心症状的基础。
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by atypical functional integration of brain regions. The vast majority of neuroimaging studies of ASD have focused on older children, adolescents, and adults with the disorder. Very little work has explored whole-brain functional connectivity of young children with ASD. Here we collected resting-state functional magnetic resonance imaging data from 58 young children (mean age 4.98 years; 29 with ASD; 29 matched healthy controls (HC)). All children were under sedation during scanning. A functional ‘connectedness’ method was first used to seek for brain regions showing atypical functional connectivity (FC) in children with ASD. Then a recurrent-seek strategy was applied to reveal atypical FC circuits in ASD children. FC matrices between regions-of-interest (ROIs) were compared between ASD and HC. Finally, a support vector regression (SVR) method was employed to assess the relationship between the FC circuits and ASD symptom severity. Two atypical FC circuits comprising 23 ROIs in ASD were revealed: one predominantly comprised brain regions involved with social cognition showing under-connectivity in ASD; the other predominantly comprised sensory-motor and visual brain regions showing over-connectivity in ASD. The SVR analysis showed that the two FC circuits were separately related to social deficits and restricted behavior scores. These findings indicate disrupted FC of neural circuits involved in the social and sensorimotor processes in young children with ASD. The finding of the atypical FC patterns in young children with ASD underscores the utility of studying younger children with the disorder, and highlights nuanced patterns of brain connectivity underlying behavior closer to disorder onset. Autism spectrum disorder (ASD) is an early-onset neurodevelopmental disorder. Understanding brain functional alterations at early ages is important for understanding biological mechanisms of ASD. Here we found two atypical brain functional circuits in young children with ASD that were related to social and sensorimotor function. These results show how atypical patterns of brain functional connectivity in young children with of ASD may underlie core symptoms of the disorder.
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