The columnar and laminar organization of inhibitory connections to neocortical excitatory cells.
The columnar and laminar organization of inhibitory connections to neocortical excitatory cells.
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DOI：
10.1038/nn.2687
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发表时间：
2011-01
影响因子：
25
通讯作者：
Miesenboeck, Gero
中科院分区：
文献类型：
--
作者：
Kaetzel, Dennis;Zemelman, Boris V.;Buetfering, Christina;Woelfel, Markus;Miesenboeck, Gero
不同的新皮层区域的细胞结构的相似性已经引起了“规范”连接的想法之间的兴奋性神经元的不同层在一个柱。目前尚不清楚是否同样普遍的组织原则也存在于抑制性新皮层回路中。在这里，我们描述并比较了初级运动（M1）、体感（S1）和视觉皮层（V1）所有主要层的局部抑制-兴奋性线路模式，在小鼠敲入系中使用遗传靶向光刺激，有条件地表达gaba能神经元中的通道视紫红质-2。对兴奋性神经元的抑制性输入主要来自三柱直径内的同一皮质层。然而，2/3层和5B层的锥体细胞亚群受到广泛的层间抑制。这些神经元在V1区突出，可能与复杂细胞相对应，在桶状皮质区数量较少，在M1区不存在。尽管抑制连接模式是刻板的，个体基序的丰度在区域和细胞之间是不同的，潜在地反映了功能特化。
The cytoarchitectonic similarities of different neocortical regions have given rise to the idea of “canonical” connectivity between excitatory neurons of different layers within a column. It is unclear whether similarly general organizational principles also exist for inhibitory neocortical circuits. Here, we delineate and compare local inhibitory-to-excitatory wiring patterns in all principal layers of primary motor (M1), somatosensory (S1), and visual cortex (V1), using genetically targeted photostimulation in a mouse knock-in line that conditionally expresses channelrhodopsin-2 in GABAergic neurons. Inhibitory inputs to excitatory neurons derive largely from the same cortical layer within a three-column diameter. However, subsets of pyramidal cells in layers 2/3 and 5B receive extensive translaminar inhibition. These neurons are prominent in V1, where they might correspond to complex cells, less numerous in barrel cortex, and absent in M1. Although inhibitory connection patterns are stereotypical, the abundance of individual motifs varies between regions and cells, potentially reflecting functional specializations.
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影响因子：
25
作者：
Dantzker, JL;Callaway, EM
通讯作者：
Callaway, EM
DOI：
10.1523/jneurosci.2093-08.2008
发表时间：
2008-10-29
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Barbour DL;Callaway EM
通讯作者：
Callaway EM
影响因子：
5.5
作者：
Blatow, M;Caputi, A;Monyer, H
通讯作者：
Monyer, H
影响因子：
7.8
作者：
Chance, FS;Abbott, LF
通讯作者：
Abbott, LF
影响因子：
16.2
作者：
Cruikshank, Scott J.;Urabe, Hayato;Nurmikko, Arto V.;Connors, Barry W.
通讯作者：
Connors, Barry W.