Coronary endothelial dysfunction: from pathogenesis to clinical implications.

Coronary endothelial dysfunction: from pathogenesis to clinical implications.
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DOI:
10.1136/openhrt-2022-002200
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发表时间:
2022-12
期刊:
影响因子:
2.7
通讯作者:
--
中科院分区:
其他
文献类型:
--
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内皮功能障碍(艾德)在动脉粥样硬化和其他血管疾病的发病机制中具有重要作用。多种危险因素,包括吸烟、高血压和糖尿病,可导致与心脏事件相关的艾德。冠状动脉内皮功能的测量需要使用有创技术来评估心外膜冠状动脉和微血管床。外周血管技术和内皮生物标志物可用于间接评估冠状动脉ED。在这篇综述中,冠状动脉艾德,我们讨论了该领域的现状,用于测量艾德的技术及其临床意义。
Endothelial dysfunction (ED) has a substantial role in the pathogenesis of atherosclerosis and other vascular diseases. Multiple risk factors, including smoking, hyperlipiadaemia and diabetes, can have associated ED, which is correlated with cardiac events. Measurement of coronary artery endothelial function requires the use of invasive techniques to assess both epicardial coronary artery and microvascular beds. Peripheral vascular techniques and endothelial biomarkers can be used to indirectly assess coronary ED. In this review of coronary artery ED, we discuss the current state of the field, the techniques used to measure ED and its clinical implications.
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