Association between insomnia symptoms and hemoglobin A1c level in Japanese men.
Association between insomnia symptoms and hemoglobin A1c level in Japanese men.
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DOI：
10.1371/journal.pone.0021420
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Yano E
中科院分区：
文献类型：
--
作者：
Kachi Y;Nakao M;Takeuchi T;Yano E
失眠症状和血红蛋白A1 c（HbA 1c）水平之间的关联的证据有限且不确定。本研究的目的是评估是否每个症状的初始，中期和末期失眠影响HbA 1c水平在日本男性。本横断面研究于2010年4月在日本一家公司的年度健康检查中检查了1，022名年龄在22-69岁之间的男性工人，他们没有糖尿病史。高HbA 1c定义为HbA 1c血液水平≥ 6.0%。三种类型的失眠症状（即，开始睡眠困难、维持睡眠困难和清晨觉醒）通过3个应答（即，持续时间超过2周，有时，很少或从不[参考组]）。高HbA 1c的总体患病率为5.2%。高HbA 1c与维持睡眠困难（趋势P = 0.002）和清晨觉醒（趋势P = 0.007）呈正线性相关。 更具体地说，在调整潜在混杂因素后，高HbA 1c与持续2周以上的睡眠维持困难显著相关（调整后比值比，6.79 [95%置信区间，1.86-24.85]）或有时（2.33 [1.19-4.55]）。高HbA 1c也与持续2周以上的清晨觉醒显著相关（3.96 [1.24-12.59]）。研究发现，失眠症状，特别是难以维持睡眠和清晨觉醒，与高HbA 1c呈剂量-反应关系。
The evidence for an association between insomnia symptoms and blood hemoglobin A1c (HbA1c) level has been limited and inconclusive. The aim of this study was to assess whether each symptom of initial, middle, and terminal insomnia influences HbA1c level in Japanese men. This cross-sectional study examined 1,022 male workers aged 22–69 years with no history of diabetes at a Japanese company's annual health check-up in April 2010. High HbA1c was defined as a blood level of HbA1c ≥6.0%. Three types of insomnia symptoms (i.e., difficulty in initiating sleep, difficulty in maintaining sleep, and early morning awakening) from the previous month were assessed by 3 responses (i.e., lasting more than 2 weeks, sometimes, and seldom or never [reference group]). The overall prevalence of high HbA1c was 5.2%. High HbA1c was positively and linearly associated with both difficulty in maintaining sleep (P for trend = .002) and early morning awakening (P for trend = .007). More specifically, after adjusting for potential confounding factors, high HbA1c was significantly associated with difficulty in maintaining sleep lasting more than 2 weeks (adjusted odds ratio, 6.79 [95% confidence interval, 1.86–24.85]) or sometimes (2.33 [1.19–4.55]). High HbA1c was also significantly associated with early morning awakening lasting more than 2 weeks (3.96 [1.24–12.59]). Insomnia symptoms, particularly difficulty in maintaining sleep and early morning awakening, were found to have a close association with high HbA1c in a dose-response relationship.
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