Neural distinctiveness and reinstatement of hippocampal representations support unitization for associations.
Neural distinctiveness and reinstatement of hippocampal representations support unitization for associations.
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DOI：
10.1016/j.brainres.2022.148143
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发表时间：
2023-01-01
期刊：
影响因子：
2.9
通讯作者：
中科院分区：
文献类型：
--
作者：
内侧颞叶（MTL）对联想记忆的成功至关重要，但并不是所有类型的联想都可以在MTL子区域内以相似的方式处理。特别是，先前的研究表明，项目内和项目间的关联不仅表现出总体回忆率的差异，而且还涉及不同的MTL子区域。项目内关联，类似于统一，利用了项目内特征之间的关联，而项目间关联形成了跨离散项目的链接。目前的工作使用功能磁共振成像和多体素分析来检查这两种类型的关联之间的神经差异。具体来说，目前的研究考察了面部职业之间的差异，作为一种函数，即配对是被视为执行给定工作的人（项内绑定），还是被视为认识从事特定工作的人（项间绑定）。结果表明，在编码时，成功回忆的与项目内和项目间关联相关的神经模式在海马体、海马体旁和嗅周皮层中是不同的。此外，两种试验类型的恢复是明显的，因此项目间试验比项目内试验在海马体中有更高的从编码到检索的神经恢复。我们得出的结论是，内部和内部关联对可能利用相似的神经区域，在编码时代表不同的激活模式。然而，为了将信息恢复到相同程度（即随后成功回忆），以相同方式编码的项目间关联可能比通过不同想象组合和特定职业编码的项目内关联恢复得更相似。这可能表明项目内关联促进更有效的恢复。
The medial temporal lobe (MTL) is critical to associative memory success, yet not all types of associations may be processed in a similar manner within MTL subregions. In particular, previous work suggests intra- and inter-item associations not only exhibit differences in overall rates of recollection, but also recruit different MTL subregions. Whereas intra-item associations, akin to unitization, take advantage of associations between within-item features, inter-item associations form links across discrete items. The current work examines the neural differences between these two types of associations using fMRI and multivoxel analyses. Specifically, the current study examines differences across face-occupation as a function of whether the pairing was viewed as a person performing the given job (intra-item binding) or a person saying they knew someone who had a particular job (inter-item binding). The results show that at encoding, successfully recollected neural patterns related to intra- and inter-item associations are distinct from one another in the hippocampus, parahippocampal and perirhinal cortex. Additionally, the two trial types are reinstated distinctly such that inter-item trials have higher neural reinstatement from encoding to retrieval compared to intra-item trials in the hippocampus. We conclude that intra- and inter-associative pairs may utilize similar neural regions that represent patterns of activation differentially at encoding. However, to reinstate information to the same degree (i.e., subsequently successfully recollected) inter-item associations, that are all encoded in the same manner, may be reinstated more similarly compared to intra-item associations that are encoded by imagining pairs differently and occupation specific. This may indicate that intra-item associations promote more efficient reinstatement.
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影响因子：
2.9
作者：
Diana RA;Van den Boom W;Yonelinas AP;Ranganath C
通讯作者：
Ranganath C
DOI：
10.1073/pnas.1610686113
发表时间：
2016-09-06
影响因子：
11.1
作者：
Chadwick, Martin J.;Anjum, Raeesa S.;Hassabis, Demis
通讯作者：
Hassabis, Demis
影响因子：
1.9
作者：
Delhaye, Emma;Bastin, Christine
通讯作者：
Bastin, Christine
DOI：
10.1037/0278-7393.34.4.730
发表时间：
2008-07
期刊：
Journal of experimental psychology. Learning, memory, and cognition
影响因子：
--
作者：
Diana RA;Yonelinas AP;Ranganath C
通讯作者：
Ranganath C
影响因子：
3.2
作者：
Park H;Rugg MD
通讯作者：
Rugg MD