Iron status in the elderly.
Iron status in the elderly.
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DOI：
10.1016/j.mad.2013.11.005
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发表时间：
2014-03
影响因子：
5.3
通讯作者：
Myint, Phyo K.
中科院分区：
文献类型：
--
作者：
Fairweather-Tait, Susan J.;Wawer, Anna A.;Gillings, Rachel;Jennings, Amy;Myint, Phyo K.
缺铁性贫血在老年人中比较常见。这主要是由于饮食不足和炎症的存在。它会导致身体机能下降，跌倒的风险增加和抑郁症。高剂量的铁补充剂可能会产生不良影响。铁的状态是很难衡量的老年人，并没有普遍认同的“截止”值。缺铁性贫血在老年人中普遍存在，特别是80岁以后。血清铁蛋白浓度也会下降，尽管没有证据表明铁储备的变化是衰老的必然结果。慢性炎症是老年人中的常见病症，使得铁状态的测量变得困难，并且可能是循环铁调素水平升高导致铁代谢的变化，从而导致全身性铁耗竭。其他的影响因素是不良的饮食和一些药物，如阿司匹林。老年人贫血会产生不良的健康后果，包括更容易跌倒和抑郁。然而，人们担心铁补充剂可能会产生不良影响，无论是在肠道中的促炎作用还是不适当的组织铁沉积。脑铁水平随着年龄相关的退行性疾病而增加，但尚不清楚这是疾病的原因还是后果，遗传因素可能起作用。为了将体内铁维持在正常范围内，需要采取个性化的方法，考虑到可能影响铁代谢的所有因素以及预防铁缺乏或过载的可用策略。
Iron-deficiency anaemia is relatively common in old age. It is mainly caused by an inadequate diet and the presence of inflammation. It leads to a decline in physical performance, increased risk of falling, and depression. High dose iron supplements may have adverse effects. Iron status is difficult to measure in elderly people and there are no universally agreed ‘cut-off’ values. Iron deficiency anaemia is prevalent in older age, particularly after the age of 80. Serum ferritin concentrations also decline, although there is no evidence to suggest that changes in iron stores are an inevitable consequence of ageing. Chronic inflammation is a common condition in older people, making the measurement of iron status difficult, and it is likely that elevated levels of circulating hepcidin are responsible for changes in iron metabolism that result in systemic iron depletion. Other contributory factors are poor diet and some medications, such as aspirin. Anaemia in older age has undesirable health outcomes, including increased susceptibility to falling and depression. However, there are concerns about possible adverse effects of iron supplements, either in relation to pro-inflammatory effects in the gut or inappropriate tissue iron deposition. Brain iron levels are increased with age-related degenerative diseases, but it is not known if this is the cause or a consequence of the disease, and genetic factors are likely to play a role. In order to maintain body iron within the normal range a personalised approach is required, taking into account all of the factors that may affect iron metabolism and the available strategies for preventing iron deficiency or overload.
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发表时间：
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