Periodontal innate immune mechanisms relevant to atherosclerosis.
Periodontal innate immune mechanisms relevant to atherosclerosis.
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DOI：
10.1111/omi.12087
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发表时间：
2015-06
影响因子：
3.7
通讯作者：
Engelke M
中科院分区：
文献类型：
--
作者：
Amar S;Engelke M
Atherosclerosis is a common cardiovascular disease in the United States. The disease is a leading cause of illness and death in the United States. Atherosclerosis is the most common cause for heart attack and stroke. Most commonly, people develop atherosclerosis as a result of diabetes, genetic risk factors, high blood pressure, a high-fat diet, obesity, high blood cholesterol levels, and smoking. However a sizable amount of patients suffering from atherosclerosis do not harbor the classical risk factors. Ongoing infections have been suggested to play a role in this process. Periodontal disease is perhaps the most common chronic infection in adults with a wide range of clinical variability and severity. Research in the past decade has shed substantial light on both the initiating infectious agents and host immunological responses in periodontal disease. Up to 46% of the general population harbors the microorganism(s) associated with periodontal disease, although many are able to limit the progression of periodontal disease or even clear the organism(s) if infected. In the last decade, several epidemiological studies have found an association between periodontal infection and atherosclerosis. This review focuses on exploring the molecular consequences of infection by pathogen that exacerbate atherosclerosis, with focus on infection by the periodontal bacterium Porphyromonas gingivalis as a running example.
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影响因子：
4.4
作者：
Amar, Salomon;Wu, Shou-chieh;Madan, Monika
通讯作者：
Madan, Monika
DOI：
10.1016/j.jebdp.2008.12.010
发表时间：
2009-03-01
期刊：
The journal of evidence-based dental practice
影响因子：
--
作者：
Dasanayake, Ananda P
通讯作者：
Dasanayake, Ananda P
DOI：
10.1161/01.atv.0000078603.90302.4a
发表时间：
2003-07-01
影响因子：
8.7
作者：
Amar, S;Gokce, N;Vita, JA
通讯作者：
Vita, JA
影响因子：
3
作者：
Cavrini, F;Sambri, V;Cevenini, R
通讯作者：
Cevenini, R
影响因子：
4.8
作者：
Bahekar, Amol Ashok;Singh, Sarabjeet;Arora, Rohit
通讯作者：
Arora, Rohit