Morphogenetic Roles of Hydrostatic Pressure in Animal Development.

Morphogenetic Roles of Hydrostatic Pressure in Animal Development.
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DOI:
10.1146/annurev-cellbio-120320-033250
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发表时间:
2022-10-06
影响因子:
11.3
通讯作者:
Di Talia, Stefano
Di Talia, Stefano
中科院分区:
生物学1区
文献类型:
--
作者:
Bagnat, Michel;Daga, Bijoy;Di Talia, Stefano

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在生物体发育过程中,器官和系统是按照遗传蓝图建立的,该蓝图产生能够执行特定生理功能的结构。有趣的是,我们已经了解到,发育组织的生理活动也有助于其自身的形态发生。具体而言,生理活动,如液体分泌和细胞收缩产生静水压力,可以作为形态发生力。在这里,我们首先回顾了静水压力的作用,在管形成在动物的发展和讨论管腔形成的数学模型。然后,我们说明了脊索作为一个流体静力学支架在脊索动物的前后轴发展的具体作用。最后,我们涵盖了一些例子,流体流动如何影响形态发生过程中的其他发展情况。了解流体力量在发育过程中的作用将是揭示控制形态发生的自组织原则的关键。
During organismal development, organs and systems are built following a genetic blueprint that produces structures capable of performing specific physiological functions. Interestingly, we have learned that the physiological activities of developing tissues also contribute to their own morphogenesis. Specifically, physiological activities such as fluid secretion and cell contractility generate hydrostatic pressure that can act as a morphogenetic force. Here, we first review the role of hydrostatic pressure in tube formation during animal development and discuss mathematical models of lumen formation. We then illustrate specific roles of the notochord as a hydrostatic scaffold in anterior-posterior axis development in chordates. Finally, we cover some examples of how fluid flows influence morphogenetic processes in other developmental contexts. Understanding how fluid forces act during development will be key for uncovering the self-organizing principles that control morphogenesis.
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