TB incidence and characteristics in the remote gulf province of Papua New Guinea: a prospective study.
TB incidence and characteristics in the remote gulf province of Papua New Guinea: a prospective study.
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DOI：
10.1186/1471-2334-14-93
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发表时间：
2014-02-20
影响因子：
3.7
通讯作者：
Pellegrini M
中科院分区：
文献类型：
--
作者：
Cross GB;Coles K;Nikpour M;Moore OA;Denholm J;McBryde ES;Eisen DP;Warigi B;Carter R;Pandey S;Harino P;Siba P;Coulter C;Mueller I;Phuanukoonnon S;Pellegrini M
巴布亚新几内亚（PNG）偏远地区结核病（TB）的发病率和特征在很大程度上是未知的。我们研究的目的是确定巴布亚新几内亚海湾省结核病的发病率，并描述可能影响疾病结局和传播的疾病特征、合并症和耐药性概况。在2012年3月至2012年6月期间，我们前瞻性地收集了274名在Kikori医院就诊并被推定诊断为结核病的患者以及在研究期间接受结核病治疗的住院患者的数据。采集痰液进行显微镜检查、GeneXpert分析、培养和分离株基因分型。我们估计2012年Kikori的结核病发病率为每10万人1290例（95% CI 1140至1460）。结核病患者合并感染艾滋病毒的比例为1.9%。32例结核病患者中有3例对利福平耐药。9个菌株的分型显示等位基因多样性，大多数与北京菌株相关。Kikori的结核病发病率是世界上最高的之一，它不是由艾滋病毒合并感染驱动的。高发病率和利福平耐药性的存在需要紧急关注，以减少该区域的大量发病率。
The incidence and characteristics of tuberculosis (TB) in remote areas of Papua New Guinea (PNG) are largely unknown. The purpose of our study was to determine the incidence of TB in the Gulf Province of PNG and describe disease characteristics, co-morbidities and drug resistance profiles that could impact on disease outcomes and transmission. Between March 2012 and June 2012, we prospectively collected data on 274 patients presenting to Kikori Hospital with a presumptive diagnosis of TB, and on hospital inpatients receiving TB treatment during the study period. Sputum was collected for microscopy, GeneXpert analysis, culture and genotyping of isolates. We estimate the incidence of TB in Kikori to be 1290 per 100,000 people (95% CI 1140 to 1460) in 2012. The proportion of TB patients co-infected with HIV was 1.9%. Three of 32 TB cases tested were rifampicin resistant. Typing of nine isolates demonstrated allelic diversity and most were related to Beijing strains. The incidence of TB in Kikori is one of the highest in the world and it is not driven by HIV co-infection. The high incidence and the presence of rifampicin resistant warrant urgent attention to mitigate substantial morbidity in the region.
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影响因子：
9.4
作者：
Blakemore, Robert;Story, Elizabeth;Alland, David
通讯作者：
Alland, David
影响因子：
168.9
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Boehme, Catharina C.;Nicol, Mark P.;Nabeta, Pamela;Michael, Joy S.;Gotuzzo, Eduardo;Tahirli, Rasim;Gler, Ma Tarcela;Blakemore, Robert;Worodria, William;Gray, Christen;Huang, Laurence;Caceres, Tatiana;Mehdiyev, Rafail;Raymond, Lawrence;Whitelaw, Andrew;Sagadevan, Kalaiselvan;Alexander, Heather;Albert, Heidi;Cobelens, Frank;Cox, Helen;Alland, David;Perkins, Mark D.
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Perkins, Mark D.
影响因子：
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Getahun, Haileyesus;Gunneberg, Christian;Nunn, Paul
通讯作者：
Nunn, Paul
影响因子：
14.9
作者：
Weniger T;Krawczyk J;Supply P;Niemann S;Harmsen D
通讯作者：
Harmsen D
影响因子：
15.3
作者：
Petroff, S A
通讯作者：
Petroff, S A