Alpha frequency modulation in the human basal ganglia is dependent on motor task
Alpha frequency modulation in the human basal ganglia is dependent on motor task
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人类基底神经节的阿尔法频率调制取决于运动任务
DOI：
--
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发表时间：
2011
影响因子：
3.4
通讯作者：
K. Bötzel
中科院分区：
文献类型：
--
作者：
Arun Singh;J. Levin;J. Mehrkens;K. Bötzel
帕金森病（PD）或肌张力障碍患者基底神经节的深度记录揭示了特定频段的局部场电位（LFP）活动。深度记录还使我们能够研究不同类型的肢体运动过程中的LFP功率谱，从而有助于阐明基底神经节在特定运动任务中的作用。因此，我们记录了双侧LFP活动与PD患者（n = 9）和苍白球内侧（GPi）的肌张力障碍患者（n = 8）的丘脑底核（ESTA）。 在手肘关节的重复被动、主动和弹道式快速伸展和屈曲的表现过程中以及在休息期间进行记录。第一个结果是，频谱在GPi和GPi中以类似的方式变化。对侧的α频率的幅度是显着较高的弹道快速运动相比，休息，被动和主动的性能，在两个patient和GPi。总之，弹道式快速运动导致α范围内的同步基底神经节活动。由于这在两个患者组（PD和肌张力障碍）中均观察到，因此我们认为该活动是任务特异性的，而不是疾病相关的。
Depth recordings from the basal ganglia of patients suffering from Parkinson’s disease (PD) or dystonia have revealed local field potential (LFP) activity in specific frequency bands. Depth recordings also allow us to study LFP power spectra during different types of limb movements, thus helping to elucidate the role of the basal ganglia in specific motor tasks. Accordingly, we recorded bilateral LFP activity from the subthalamic nucleus (STN) of patients with PD (n = 9) and from the globus pallidus internum (GPi) of patients with dystonia (n = 8). Recordings were taken during the performance of repetitive passive, active and ballistic fast extensions and flexions of the elbow joint and during rest. The first result was that the frequency spectra varied task‐specifically in a similar fashion in GPi and STN. The amplitude of the alpha frequency on the contralateral side was significantly higher in ballistic fast movements compared with rest, passive and active performance in both STN and GPi. In conclusion, ballistic fast movements cause synchronized basal ganglia activity in the alpha range. Because this was seen in both patient groups (PD and dystonia) we consider this activity as task‐specific rather than disease‐related.
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影响因子：
14.5
作者：
Levy, R;Ashby, P;Dostrovsky, JO
通讯作者：
Dostrovsky, JO
影响因子：
2.5
作者：
Starr, PA;Rau, GM;Turner, RS
通讯作者：
Turner, RS
猴子苍白球局部失活期间手臂位置、运动和丘脑放电控制的变化。
DOI：
10.1152/jn.1996.75.3.1087
发表时间：
1996
期刊：
Journal of neurophysiology.
影响因子：
--
作者：
Inase,M;Buford,JA;Anderson,ME
通讯作者：
Anderson,ME
影响因子：
14.5
作者：
Crone, NE;Miglioretti, DL;Lesser, RP
通讯作者：
Lesser, RP