The Zfhx3-Mediated Axis Regulates Sleep and Interval Timing in Mice.
The Zfhx3-Mediated Axis Regulates Sleep and Interval Timing in Mice.
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DOI：
10.1016/j.celrep.2016.06.017
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发表时间：
2016-07-19
期刊：
影响因子：
8.8
通讯作者：
Tucci V
中科院分区：
文献类型：
--
作者：
Balzani E;Lassi G;Maggi S;Sethi S;Parsons MJ;Simon M;Nolan PM;Tucci V
受转录因子Zfhx3调控的AT基序依赖的轴影响小鼠的生物钟。特别是，Zfhx3功能的获得显著缩短了昼夜节律，并改变了一类重要的神经肽的转录活性，这些神经肽控制着下丘脑视交叉上核(SCN)的细胞间信号传递。ZFHX3/AT轴揭示了对生物钟的一种重要的、主要是细胞非自主的控制。在这里，通过研究最近发现的昼夜节律小鼠突变体Zfhx3Sci/+，我们发现了对睡眠稳态的重大影响，这一现象在规范的昼夜节律时钟系统之外，并受到这些神经肽在电路水平上的活动的调节。我们发现，Zfhx3Sci/+突变在小鼠的每小时尺度(即提前的昼夜节律)和秒至分钟尺度(即预期行为反应)上都加速了昼夜节律。体内结果伴随着Zfhx3Sci/+依赖网络的蛋白质-蛋白质相互作用中显著存在的睡眠靶点。
An AT motif-dependent axis, modulated by the transcription factor Zfhx3, influences the circadian clock in mice. In particular, gain of function of Zfhx3 significantly shortens circadian rhythms and alters the transcriptional activity of an important class of neuropeptides that controls intercellular signaling in the suprachiasmatic nucleus (SCN) of the hypothalamus. The ZFHX3/AT axis revealed an important, largely cell-nonautonomous control of the circadian clock. Here, by studying the recently identified circadian mouse mutant Zfhx3Sci/+, we identify significant effects on sleep homeostasis, a phenomenon that is outside the canonical circadian clock system and that is modulated by the activity of those neuropeptides at a circuit level. We show that the Zfhx3Sci/+ mutation accelerates the circadian clock at both the hourly scale (i.e., advancing circadian rhythms) and the seconds-to-minutes scale (i.e., anticipating behavioral responses) in mice. The in vivo results are accompanied by a significant presence of sleep targets among protein-protein interactions of the Zfhx3Sci/+-dependent network.
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G：Profiler- - 用于基因列表功能解释的Web服务器（2011年更新）。
影响因子：
14.9
作者：
Reimand J;Arak T;Vilo J
通讯作者：
Vilo J
影响因子：
64.5
作者：
Parsons MJ;Brancaccio M;Sethi S;Maywood ES;Satija R;Edwards JK;Jagannath A;Couch Y;Finelli MJ;Smyllie NJ;Esapa C;Butler R;Barnard AR;Chesham JE;Saito S;Joynson G;Wells S;Foster RG;Oliver PL;Simon MM;Mallon AM;Hastings MH;Nolan PM
通讯作者：
Nolan PM
影响因子：
4
作者：
Piggins, HD;Cutler, DJ
通讯作者：
Cutler, DJ
DOI：
10.1037/0097-7403.25.1.3
发表时间：
1999-01-01
期刊：
JOURNAL OF EXPERIMENTAL PSYCHOLOGY-ANIMAL BEHAVIORAL PROCESSES
影响因子：
--
作者：
Crystal, JD
通讯作者：
Crystal, JD
影响因子：
2.9
作者：
Cordes, Sara;Gallistel, C. R.
通讯作者：
Gallistel, C. R.