Hyperactivation in Cognitive Control and Visual Attention Brain Regions During Emotional Interference in Adolescent Depression.
Hyperactivation in Cognitive Control and Visual Attention Brain Regions During Emotional Interference in Adolescent Depression.
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DOI：
10.1016/j.bpsc.2016.09.001
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发表时间：
2017-07
期刊：
影响因子：
--
通讯作者：
Gotlib IH
中科院分区：
文献类型：
--
作者：
Colich NL;Ho TC;Foland-Ross LC;Eggleston C;Ordaz SJ;Singh MK;Gotlib IH
重度抑郁障碍（MDD）患者的特点是对负面情绪材料的注意偏倚。虽然有证据表明，额扣带区域的异常功能可能是这些偏见的基础，但我们对抑郁青少年负面情绪偏见的神经相关性知之甚少。18名被诊断为重度抑郁症的青少年和21名健康对照（CTL）青少年在执行情绪分心任务时进行了功能磁共振成像。在每个试验中，参与者都看到与任务相关的房屋配对和与任务无关的面孔配对。参与者指出房子对是否相同，而忽略了面孔对，这些面孔要么是恐惧的、悲伤的，要么是中性的。尽管两组之间的行为表现（反应时间和准确性）相同，但患有MDD的青少年在忽视恐惧面孔和中性面孔时表现出更大的额扣带区（包括背前扣带皮层（dACC）和额下回/额中回（IFG/MFG））和枕顶叶区（包括枕外侧皮层和顶叶上小叶）的激活。对这些试验条件的反应时间也与IFG/MFG和侧枕皮质的激活呈负相关，这表明这些区域被激活是为了有效地忽略情绪干扰。在忽略悲伤的脸和中性的脸、恐惧的脸和悲伤的脸时，各组的结果没有差异。与CTL青少年相比，MDD青少年的认知控制和视觉注意区域的激活程度更高，这反映了在下调威胁相关刺激时更大的认知需求。
Individuals with Major Depressive Disorder (MDD) are characterized by biases in attention to negative emotional material. While there is evidence that anomalous functioning in frontocingulate regions may underlie these biases, we know little about the neural correlates of negative emotional biases in depressed adolescents. Eighteen adolescents diagnosed with MDD and 21 matched healthy control (CTL) adolescents underwent fMRI while performing an emotional distractor task. On each trial participants were presented with task-relevant house pairs and task-irrelevant face pairs. Participants indicated whether the house pairs were identical while ignoring the face pairs, which were either fearful, sad, or neutral. Despite equivalent behavioral performance (response time and accuracy) between groups, adolescents with MDD exhibited greater activation in frontocingulate regions, including dorsal anterior cingulate cortex (dACC) and inferior frontal gyrus/middle frontal gyrus (IFG/MFG), and occipitoparietal regions, including lateral occipital cortex and superior parietal lobule when ignoring fearful versus neutral faces. Response times to these trial conditions also correlated negatively with activation in IFG/MFG and lateral occipital cortex suggesting these regions are recruited in order to effectively ignore emotional distractors. Groups did not differ when ignoring sad versus neutral faces or fearful versus sad faces. Adolescents with MDD recruit both cognitive control and visual attention regions to a greater degree than do CTL adolescents, reflecting greater cognitive demand when downregulating threat-related stimuli.
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影响因子：
3.8
作者：
Ho TC;Zhang S;Sacchet MD;Weng H;Connolly CG;Henje Blom E;Han LK;Mobayed NO;Yang TT
通讯作者：
Yang TT
影响因子：
2.3
作者：
Eugene, Fanny;Joormann, Jutta;Cooney, Rebecca E.;Atlas, Lauren Y.;Gotlib, Ian H.
通讯作者：
Gotlib, Ian H.
影响因子：
--
作者：
Beesdo, Katja;Lau, Jennifer Y. F.;Guyer, Amanda E.;McClure-Tone, Erin B.;Monk, Christopher S.;Nelson, Eric E.;Fromm, Stephen J.;Goldwin, Michelle A.;Wittchen, Hans-Ulrich;Leibenluft, Ellen;Erns, Monique;Pine, Daniel S.
通讯作者：
Pine, Daniel S.
影响因子：
11.3
作者：
Essau, Cecilia A.
通讯作者：
Essau, Cecilia A.
影响因子：
25
作者：
Bishop, S;Duncan, J;Lawrence, AD
通讯作者：
Lawrence, AD