Occupational sun exposure and risk of melanoma according to anatomical site.
Occupational sun exposure and risk of melanoma according to anatomical site.
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DOI：
10.1002/ijc.28603
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发表时间：
2014-06-01
影响因子：
6.4
通讯作者：
Cust, Anne E.
中科院分区：
文献类型：
--
作者：
Vuong, Kylie;McGeechan, Kevin;Armstrong, Bruce K.;Cust, Anne E.
虽然晒伤和间歇性阳光照射与黑色素瘤风险增加有关，但大多数研究发现职业（更连续的模式）阳光照射与黑色素瘤风险之间存在零或负相关。黑色素瘤与职业性日光暴露的相关性可能因解剖部位而异，一些研究发现与头部和颈部的黑色素瘤呈正相关。我们使用两项多中心基于人群的病例对照研究的数据，根据解剖部位检查了职业性阳光暴露（自我报告的工作日阳光暴露）与黑色素瘤风险之间的关联：澳大利亚黑色素瘤家族研究（588例，472例对照）和基因，环境和黑色素瘤研究（GEM; 1079例，2181例对照）。非条件logistic回归用于估计比值比（OR）及其95%置信区间，调整潜在混杂因素。在两项研究中，职业性日光暴露与总体或不同身体部位的黑色素瘤风险均不呈正相关。GEM研究发现，职业性阳光照射与头部和颈部黑色素瘤之间存在负相关关系（最高与最低四分位数的OR：0.56，95%CI 0.36-0.86，P趋势0.02），以及工作日总日照量与上肢黑色素瘤发生率之间的关系。（最高与最低四分位数的OR：0.66，95% CI 0.42-1.02，P趋势0.03）。我们的研究结果表明，职业性日光暴露不会增加患黑色素瘤的风险，即使是头部和颈部的黑色素瘤。这一发现似乎不是由于周末阳光照射的职业阳光暴露的负面混杂。
Although sunburn and intermittent sun exposures are associated with increased melanoma risk, most studies have found null or inverse associations between occupational (more continuous pattern) sun exposure and melanoma risk. The association of melanoma with occupational sun exposure may differ according to anatomical site, with some studies finding a positive association with melanoma on the head and neck. We examined the association between occupational sun exposure (self-reported weekday sun exposure) and melanoma risk according to anatomical site, using data from two multi-centre population-based case-control studies: the Australian Melanoma Family Study (588 cases, 472 controls) and the Genes, Environment and Melanoma study (GEM; 1079 cases, 2181 controls). Unconditional logistic regression was used to estimate odds ratios (OR) and their 95% confidence intervals, adjusting for potential confounders. Occupational sun exposure was not positively associated with melanoma risk overall or at different body sites in both studies. The GEM study found inverse associations between occupational sun exposure and melanoma on the head and neck (OR for highest vs. lowest quartile: 0.56, 95% CI 0.36-0.86, Ptrend 0.02), and between the proportion of total sun exposure occurring on weekdays and melanoma on the upper limbs (OR for highest vs. lowest quartile: 0.66, 95% CI 0.42-1.02, Ptrend 0.03). Our results suggest that occupational sun exposure does not increase risk of melanoma, even of melanomas situated on the head and neck. This finding appeared not to be due to negative confounding of occupational sun exposure by weekend sun.
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影响因子：
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通讯作者：
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