USP27X negatively regulates antiviral signaling by deubiquitinating RIG-I
USP27X negatively regulates antiviral signaling by deubiquitinating RIG-I
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USP27X 通过去泛素化 RIG-I 负向调节抗病毒信号
DOI：
10.1371/journal.ppat.1008293
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发表时间：
2020-02
期刊：
影响因子：
--
通讯作者：
Sun Qinmiao
中科院分区：
文献类型：
--
作者：
Tao Xinyue;Chu Bei;Xin Di;Li Lin;Sun Qinmiao
RIG-I在响应RNA病毒的抗病毒先天免疫反应的病原体传感和激活中起着重要作用。 RIG-I介导的信号必须得到精确控制，以维持先天的免疫信号稳态。先前的研究Demonst
RIG-I plays important roles in pathogen sensing and activation of antiviral innate immune responses in response to RNA viruses. RIG-I-mediated signaling must be precisely controlled to maintain innate immune signaling homeostasis. Previous studies demonstrated that lysine 63 (K63)-linked polyubiquitination of RIG-I is vital for its activation, but the mechanisms through which RIG-I is deubiquitinated to control innate immune responses are not well understood. Here we identified USP27X as a negative regulator of antiviral signaling in response to RNA viruses through siRNA library screening. Further functional studies indicated that USP27X negatively modulated RIG-I-mediated antiviral signaling in a deubiquitinase-dependent manner. Mechanistically, we found that USP27X removed K63-linked polyubiquitin chains from RIG-I to negatively modulate type I interferon signaling. Collectively, these studies uncover a novel negative regulatory role of USP27X in targeting RIG-I to balance innate immune responses.
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影响因子：
32.4
作者：
Loo YM;Gale M Jr
通讯作者：
Gale M Jr
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影响因子：
16.6
作者：
Lin W;Zhang J;Lin H;Li Z;Sun X;Xin D;Yang M;Sun L;Li L;Wang H;Chen D;Sun Q
通讯作者：
Sun Q
影响因子：
64.5
作者：
Zeng W;Sun L;Jiang X;Chen X;Hou F;Adhikari A;Xu M;Chen ZJ
通讯作者：
Chen ZJ
影响因子：
32.4
作者：
Paludan SR;Bowie AG
通讯作者：
Bowie AG
影响因子：
7.7
作者：
Friedman, Constantin S.;O'Donnell, Marie Anne;Ting, Adrian T.
通讯作者：
Ting, Adrian T.