A cognitive training intervention increases resting cerebral blood flow in healthy older adults.
A cognitive training intervention increases resting cerebral blood flow in healthy older adults.
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DOI：
10.3389/neuro.09.016.2010
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发表时间：
2010
影响因子：
2.9
通讯作者：
Laurienti PJ
中科院分区：
文献类型：
--
作者：
Mozolic JL;Hayasaka S;Laurienti PJ
健康的老龄化通常伴随着认知能力的下降，以及大脑结构和功能的改变。在这里，我们报告了一项随机对照试验的结果，旨在确定一种新的认知训练计划对健康老年人静息脑血流量（CBF）和灰质（GM）体积的影响。66名健康的老年人参加了为期8周的针对注意力和注意力分散的训练计划或教育控制计划。与对照组相比，该训练方案使前额皮质的静息CBF显著增加。血流量的增加与训练后注意力分散的敏感性降低有关，但与GM体积的改变无关。这些数据表明，认知训练可以改善健康老年人的静息脑血流，脑灌注率可能是认知训练比容量分析更敏感的指标。
Healthy aging is typically accompanied by some decline in cognitive performance, as well as by alterations in brain structure and function. Here we report the results of a randomized, controlled trial designed to determine the effects of a novel cognitive training program on resting cerebral blood flow (CBF) and gray matter (GM) volume in healthy older adults. Sixty-six healthy older adults participated in 8 weeks of either a training program targeting attention and distractibility or an educational control program. This training program produced significantly larger increases in resting CBF to the prefrontal cortex than the control program. Increases in blood flow were associated with reduced susceptibility to distraction after training, but not with alterations in GM volume. These data demonstrate that cognitive training can improve resting CBF in healthy older adults and that cerebral perfusion rates may be a more sensitive indicator of the benefits of cognitive training than volumetric analyses.
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