Association of intrauterine exposure to maternal diabetes and obesity with type 2 diabetes in youth: the SEARCH Case-Control Study.
Association of intrauterine exposure to maternal diabetes and obesity with type 2 diabetes in youth: the SEARCH Case-Control Study.
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宫内接触母体糖尿病和肥胖症与青少年2型糖尿病的关联：搜索病例对照研究。
DOI：
10.2337/dc07-2417
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发表时间：
2008-07
期刊：
影响因子：
16.2
通讯作者：
Hamman, Richard F.
中科院分区：
文献类型：
--
作者：
Dabelea, Dana;Mayer-Davis, Elizabeth J.;Lamichhane, Archana P.;D'Agostino, Ralph B.;Liese, Angela D.;Vehik, Kendra S.;Narayan, K. M. Venkat;Zeitler, Phillip;Hamman, Richard F.
妊娠-关于宫内暴露于母体糖尿病和肥胖与不同青年中2型糖尿病之间的关联的数据有限。这些关联在参与ESTA病例对照研究的非裔美国人、西班牙裔和非西班牙裔白色青年中进行了探讨。研究设计和方法-共有79名2型糖尿病青年和190名年龄在10-22岁的非糖尿病对照青年参加了研究访问。在子宫内暴露于母体糖尿病和肥胖症是由亲生母亲回忆的。与非糖尿病对照青年相比，患有2型糖尿病的青年更有可能在子宫内暴露于母体糖尿病或肥胖（P < 0.0001）。在调整后代年龄、性别和种族/民族后，母亲糖尿病暴露（比值比[OR] 5.7 [95%CI 2.4-13.4]）和母亲肥胖暴露（2.8 [1.5-5.2]）与2型糖尿病独立相关。调整其他围产期和社会经济因素并没有改变这些协会。当增加后代BMI时，子宫内暴露于肥胖和2型糖尿病之间的关联的OR向零衰减（OR 1.1 [0.5-2.4]）。总体而言，47.2%（95%CI 30.9-63.5）的青年2型糖尿病可归因于宫内暴露于母体糖尿病和肥胖。结论：母体糖尿病和肥胖的宫内暴露与青年2型糖尿病密切相关。除了儿童肥胖症外，预防工作可能需要针对越来越多的怀孕并发肥胖症和糖尿病。
OBJECTIVE—Limited data exist on the association between in utero exposure to maternal diabetes and obesity and type 2 diabetes in diverse youth. These associations were explored in African-American, Hispanic, and non-Hispanic white youth participating in the SEARCH Case-Control Study. RESEARCH DESIGN AND METHODS—A total of 79 youth with type 2 diabetes and 190 nondiabetic control youth aged 10–22 years attended a research visit. In utero exposures to maternal diabetes and obesity were recalled by biological mothers. RESULTS—Youth with type 2 diabetes were more likely to have been exposed to maternal diabetes or obesity in utero than were nondiabetic control youth (P < 0.0001 for each). After adjusting for offspring age, sex, and race/ethnicity, exposure to maternal diabetes (odds ratio [OR] 5.7 [95% CI 2.4–13.4]) and exposure to maternal obesity (2.8 [1.5–5.2]) were independently associated with type 2 diabetes. Adjustment for other perinatal and socioeconomic factors did not alter these associations. When offspring BMI was added, the OR for the association between in utero exposure to obesity and type 2 diabetes was attenuated toward the null (OR 1.1 [0.5–2.4]). Overall, 47.2% (95% CI 30.9–63.5) of type 2 diabetes in youth could be attributed to intrauterine exposure to maternal diabetes and obesity. CONCLUSIONS—Intrauterine exposures to maternal diabetes and obesity are strongly associated with type 2 diabetes in youth. Prevention efforts may need to target, in addition to childhood obesity, the increasing number of pregnancies complicated by obesity and diabetes.
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影响因子：
8
作者：
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通讯作者：
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