Virus-Based Nanoparticles as Versatile Nanomachines.
Virus-Based Nanoparticles as Versatile Nanomachines.
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DOI：
10.1146/annurev-virology-100114-055141
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发表时间：
2015-11
影响因子：
11.3
通讯作者：
Steinmetz NF
中科院分区：
文献类型：
--
作者：
Koudelka KJ;Pitek AS;Manchester M;Steinmetz NF
纳米工程正在彻底改变我们预防、检测和治疗疾病的方式。病毒在这些发展中发挥了特殊的作用，因为它们可以作为预制的纳米支架，具有独特的特性，并且很容易被修改。病毒颗粒的内部可以包裹和保护敏感的化合物，而外部可以改变以精确定义的阵列显示大小分子。病毒的这些性质，沿着它们固有的生物相容性，已经导致它们作为积极靶向药物递送系统的发展，其扩展并改善了当前的药物选择。病毒是天然免疫原性的，并且在其表面上展示的抗原已被用于产生针对病原体的疫苗并打破自身耐受性以启动对功能失调蛋白质的免疫应答。病毒上密集和特异性对齐的成像剂允许高分辨率和非侵入性可视化工具比以前更早地检测和治疗疾病。病毒的这些和未来的应用在纳米技术和医学学科中创造了一个令人兴奋的新领域。
Nanoscale engineering is revolutionizing the way we prevent, detect, and treat diseases. Viruses have played a special role in these developments because they can function as prefabricated nanoscaffolds that have unique properties and are easily modified. The interiors of virus particles can encapsulate and protect sensitive compounds, while the exteriors can be altered to display large and small molecules in precisely defined arrays. These properties of viruses, along with their innate biocompatibility, have led to their development as actively targeted drug delivery systems that expand on and improve current pharmaceutical options. Viruses are naturally immunogenic, and antigens displayed on their surface have been used to create vaccines against pathogens and to break self-tolerance to initiate an immune response to dysfunctional proteins. Densely and specifically aligned imaging agents on viruses have allowed for high-resolution and noninvasive visualization tools to detect and treat diseases earlier than previously possible. These and future applications of viruses have created an exciting new field within the disciplines of both nanotechnology and medicine.
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影响因子：
7.3
作者：
Awate S;Babiuk LA;Mutwiri G
通讯作者：
Mutwiri G
影响因子：
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作者：
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影响因子：
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通讯作者：
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作者：
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