Hepatotoxic seafood poisoning (HSP) due to microcystins: a threat from the ocean?
Hepatotoxic seafood poisoning (HSP) due to microcystins: a threat from the ocean?
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DOI：
10.3390/md11082751
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发表时间：
2013-08-05
期刊：
影响因子：
5.4
通讯作者：
Sainis I
中科院分区：
文献类型：
--
作者：
Vareli K;Jaeger W;Touka A;Frillingos S;Briasoulis E;Sainis I
蓝藻水华是全球淡水生态系统的一个主要且日益严重的问题，越来越关注公共健康，已知的平均60%的水华是有毒的。研究最多的蓝藻毒素属于环七肽肝毒素家族，称为微囊藻毒素。微囊藻毒素是一种稳定的亲水性环七肽，通过有机阴离子转运蛋白(OATP)摄取细胞后可能导致细胞损伤。它们的细胞内生物效应可能包括抑制蛋白磷酸酶催化亚单位(PP1和PP2A)和谷胱甘肽的耗竭。蓝藻产生的微囊藻毒素如果污染饮用水或食物，就会对人类健康构成严重问题。这些毒素是造成人类死亡以及野生动物和家畜持续广泛中毒的共同原因。虽然在淡水生态系统中，微囊藻毒素对水生生物的中毒已被广泛记录在案，但在海洋环境中，这种中毒只是偶尔才有报告。此外，这些中毒可归因于淡水蓝藻物种入侵盐度较低的海洋(如波罗的海)或淡水微囊藻毒素排入海洋。然而，最近的数据表明，一些世界性海洋物种也在海洋中产生微囊藻毒素，因此，肝毒性海鲜中毒(HSP)越来越被认为是继食用受污染的海鲜之后的一个主要健康风险。
Cyanobacterial blooms are a major and growing problem for freshwater ecosystems worldwide that increasingly concerns public health, with an average of 60% of blooms known to be toxic. The most studied cyanobacterial toxins belong to a family of cyclic heptapeptide hepatotoxins, called microcystins. The microcystins are stable hydrophilic cyclic heptapeptides with a potential to cause cell damage following cellular uptake via organic anion-transporting proteins (OATP). Their intracellular biologic effects presumably involve inhibition of catalytic subunits of protein phosphatases (PP1 and PP2A) and glutathione depletion. The microcystins produced by cyanobacteria pose a serious problem to human health, if they contaminate drinking water or food. These toxins are collectively responsible for human fatalities, as well as continued and widespread poisoning of wild and domestic animals. Although intoxications of aquatic organisms by microcystins have been widely documented for freshwater ecosystems, such poisonings in marine environments have only occasionally been reported. Moreover, these poisonings have been attributed to freshwater cyanobacterial species invading seas of lower salinity (e.g., the Baltic) or to the discharge of freshwater microcystins into the ocean. However, recent data suggest that microcystins are also being produced in the oceans by a number of cosmopolitan marine species, so that Hepatotoxic Seafood Poisoning (HSP) is increasingly recognized as a major health risk that follows consumption of contaminated seafood.
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影响因子：
3.2
作者：
Christiansen, G;Fastner, J;Dittmann, E
通讯作者：
Dittmann, E
影响因子：
10.4
作者：
Gilroy, DJ;Kauffman, KW;Chu, FS
通讯作者：
Chu, FS
影响因子：
10.4
作者：
Feurstein D;Kleinteich J;Heussner AH;Stemmer K;Dietrich DR
通讯作者：
Dietrich DR
影响因子：
3
作者：
CARMICHAEL, WW
通讯作者：
CARMICHAEL, WW
影响因子：
2.8
作者：
ANDERSEN, RJ;LUU, HA;WILLIAMS, DE
通讯作者：
WILLIAMS, DE