From facial mimicry to emotional empathy: a role for norepinephrine?
From facial mimicry to emotional empathy: a role for norepinephrine?
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DOI：
10.1080/17470911003656330
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发表时间：
2010
影响因子：
2
通讯作者：
Critchley HD
中科院分区：
文献类型：
--
作者：
Harrison NA;Morgan R;Critchley HD
模仿他人情绪化面部表情的倾向预示着同情心，可能是精神病的生理标志。杏仁核，扣带运动皮层（M3，M4）和面神经核之间的解剖连接表明了模仿的潜在神经解剖学基础，尽管药理学影响在很大程度上是未知的。去甲肾上腺素调节选择性地损害负面情绪识别，反映了在处理移情引发面部表情的潜在作用。我们研究了单剂量普萘洛尔（β-肾上腺素受体阻滞剂）和瑞博西汀（选择性去甲肾上腺素再摄取抑制剂）对悲伤、愤怒和快乐的自动面部模仿的影响，以及模仿和移情之间的关系。45名健康志愿者被随机分配至40 mg普萘洛尔或4 mg瑞博塞。服药两小时后，受试者观看并评定悲伤、愤怒和快乐的面部表情，同时记录皱眉肌、肌肉肌和颏肌肌电图。特质情绪同理心采用平衡情绪同理心量表进行测量。肌电图证实了情绪特异性拟态以及皱眉肌拟态与共情之间的关系。去甲肾上腺素调节并不改变模仿任何表情或影响模仿和共情之间的关系。波纹管，而不是natomaticus模仿预测特质同理心，与杏仁核和M3编码上面部肌肉代表之间的解剖连接性更大。虽然影响情绪感知，去甲肾上腺素不影响情绪面部模仿或其与特质共情的关系。
Tendency to mimic others’ emotional facial expressions predicts empathy and may represent a physiological marker of psychopathy. Anatomical connectivity between amygdala, cingulate motor cortex (M3, M4), and facial nucleus demonstrates a potential neuroanatomical substrate for mimicry, though pharmacological influences are largely unknown. Norepinephrine modulation selectively impairs negative emotion recognition, reflecting a potential role in processing empathy-eliciting facial expressions. We examined effects of single doses of propranolol (beta-adrenoceptor blocker) and reboxetine (selective norepinephrine reuptake inhibitor) on automatic facial mimicry of sadness, anger, and happiness, and the relationship between mimicry and empathy. Forty-five healthy volunteers were randomized to 40 mg propranolol or 4 mg reboxetine. Two hours after drug subjects viewed and rated facial expressions of sadness, anger, and happiness, while corrugator, zygomatic, and mentalis EMG were recorded. Trait emotional empathy was measured using the Balanced Emotional Empathy Scale. EMG confirmed emotion-specific mimicry and the relationship between corrugator mimicry and empathy. Norepinephrine modulation did not alter mimicry to any expression or influence the relationship between mimicry and empathy. Corrugator but not zygomaticus mimicry predicts trait empathy, consistent with greater anatomical connectivity between amygdala and M3 coding upper facial muscle representations. Although influencing emotion perception, norepinephrine does not influence emotional facial mimicry or its relationship with trait empathy.
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影响因子：
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