Discharge dependencies of amygdala central nucleus neurons to the cardiac and respiratory cycle following local cocaine administration.
Discharge dependencies of amygdala central nucleus neurons to the cardiac and respiratory cycle following local cocaine administration.
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局部可卡因给药后杏仁核中央核神经元对心脏和呼吸周期的放电依赖性。
DOI：
10.1016/0014-2999(92)90800-j
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发表时间：
1992
影响因子：
5
通讯作者：
Harper,RM
中科院分区：
文献类型：
--
作者：
Ni,H;Zhang,J;Harper,RK;Harper,RM
We examined dependencies of amygdala central nucleus neuronal discharge to the cardiac and resniratory cycles in freely behaving cats following local microinjcction of cocaine (100 μg/0.2 μl). Cross-correlation histograms showed cycle-by-cycle dependencies between neuronal discharge and the cardiac and respiratory cycles in 10 of 30 cells and 7 of 30 cells, respectively, during baseline periods. After cocaine delivery, the discharge rate of half of the central nucleus of the amygdala cells (16/30, 53%) were partly or completely inhibited in a reversible manner. Excluding cardiac- and respiratory-dependent neurons which ceased firing after cocaine, more than half (5/8) of the remaining cardiac and two-thirds (4/6) of respiratory-dependent neurons altered discharge dependencies following cocaine administration. Of the cells that did not exhibit cardiac and respiratory dependencies pre-cocaine, 2 of 20 developed cardiac correlations and 3 of 23 developed respiratory correlations following cocaine administration. We speculate that a portion of the cardiac and respiratory responses induced by cocaine may be mediated through the central nucleus of the amygdala.
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DOI：
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