Quantitative tool for rapid disease mapping using optical coherence tomography images of azoxymethane-treated mouse colon.
Quantitative tool for rapid disease mapping using optical coherence tomography images of azoxymethane-treated mouse colon.
复制标题
使用氧化偶氮甲烷处理的小鼠结肠的光学相干断层扫描图像进行快速疾病绘图的定量工具。
DOI：
10.1117/1.3446674
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发表时间：
2010
影响因子：
3.5
通讯作者：
Barton,JenniferK
中科院分区：
文献类型：
--
作者：
Winkler,AmyM;Rice,PhotiniFS;Drezek,RebekahA;Barton,JenniferK
Optical coherence tomography (OCT) can provide new insight into disease progression and therapy by enabling nondestructive, serial imaging ofin vivocancer models. In previous studies, we have shown the utility of endoscopic OCT for identifying adenomas in the azoxymethane-treated mouse model of colorectal cancer and tracking disease progression over time. Because of improved imaging speed made possible through Fourier domain imaging, three-dimensional imaging of the entire mouse colon is possible. Increased amounts of data can facilitate more accurate classification of tissue but require more time on the part of the researcher to sift through and identify relevant data. We present quantitative software for automatically identifying potentially diseased areas that can be used to create a two-dimensional “disease map” from a three-dimensional Fourier domain OCT data set. In addition to sensing inherent changes in tissue that occur during disease development, the algorithm is sensitive to exogeneous highly scattering gold nanoshells that can be targeted to disease biomarkers. The results of the algorithm were compared to histological diagnosis. The algorithm was then used to assess the ability of gold nanoshells targeted to epidermal growth factor receptorin vivoto enable functional OCT imaging.
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影响因子：
3.8
作者：
Adler DC;Zhou C;Tsai TH;Schmitt J;Huang Q;Mashimo H;Fujimoto JG
通讯作者：
Fujimoto JG
影响因子：
56.9
作者：
Tearney, GJ;Brezinski, ME;Fujimoto, JG
通讯作者：
Fujimoto, JG
影响因子：
9.3
作者：
Jäckle, S;Gladkova, N;Soehendra, N
通讯作者：
Soehendra, N
散射敏感显微技术可识别小鼠结肠超高分辨率光学相干断层扫描中的对比粘膜结构
DOI：
10.1117/12.763968
发表时间：
2008
期刊：
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
影响因子：
--
作者：
A. Tumlinson;L. Hariri;W. Drexler;J. Barton
通讯作者：
J. Barton
致密组织临床光学相干断层扫描数据的自动分类
影响因子：
2.1
作者：
F. Bazant;N. Stone
通讯作者：
N. Stone