Neural reward circuit dysfunction as a risk factor for bipolar spectrum disorders and substance use disorders: A review and integration.
Neural reward circuit dysfunction as a risk factor for bipolar spectrum disorders and substance use disorders: A review and integration.
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DOI：
10.1016/j.cpr.2021.102035
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发表时间：
2021-07
影响因子：
12.8
通讯作者：
Alloy LB
中科院分区：
文献类型：
--
作者：
Bart CP;Titone MK;Ng TH;Nusslock R;Alloy LB
双相谱系障碍（BSD）和物质使用障碍（SUD）与神经奖赏功能障碍有关。然而，目前还不清楚神经奖励功能的模式是什么，或者神经奖励功能是否解释了它们的高共现率。本文概述了关于BSD和SUD中神经奖励敏感性的单独文献。我们提供了一个系统的审查相关的35项研究，以确定神经奖励功能的脆弱性，BSD和SUD。这些研究包括那些研究神经奖励处理的金钱奖励任务与前瞻性设计预测SUD的初始发作，家族风险研究，检查未受影响的后代或一级亲属的家庭成员与BSD或SUD，和研究，检查个人与BSD或SUD谁是目前没有发作的障碍。该综述的结果强调，与奖励和认知控制相关的神经区域的异常反应和连接会导致BSD和SUD的发展风险。讨论的重点是现存文献的局限性。我们的结论与理解异常的神经奖励反应如何可能构成一个脆弱性的发展BSD和SUD的整合和理论模型。
Bipolar spectrum disorders (BSDs) and substance use disorders (SUDs) are associated with neural reward dysfunction. However, it is unclear what pattern of neural reward function underlies pre-existing vulnerability to BSDs and SUDs, or whether neural reward function explains their high co-occurrence. The current paper provides an overview of the separate literatures on neural reward sensitivity in BSDs and SUDs. We provide a systematic review of 35 studies relevant to identifying neural reward function vulnerability to BSDs and SUDs. These studies include those examining neural reward processing on a monetary reward task with prospective designs predicting initial onset of SUDs, familial risk studies that examine unaffected offspring or first-degree relatives of family members with BSDs or SUDs, and studies that examine individuals with BSDs or SUDs who are not currently in an episode of the disorder. Findings from the review highlight that aberrant responding and connectivity across neural regions associated with reward and cognitive control confers risk for the development of BSDs and SUDs. Discussion focuses on limitations of the extant literature. We conclude with an integration and theoretical model for understanding how aberrant neural reward responding may constitute a vulnerability to the development of both BSDs and SUDs.
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影响因子：
16.6
作者：
Büchel C;Peters J;Banaschewski T;Bokde AL;Bromberg U;Conrod PJ;Flor H;Papadopoulos D;Garavan H;Gowland P;Heinz A;Walter H;Ittermann B;Mann K;Martinot JL;Paillère-Martinot ML;Nees F;Paus T;Pausova Z;Poustka L;Rietschel M;Robbins TW;Smolka MN;Gallinat J;Schumann G;Knutson B;IMAGEN consortium
通讯作者：
IMAGEN consortium
沿双极光谱的进展：从双极光谱条件转换为双极I和II疾病的纵向研究。
影响因子：
4.6
作者：
Alloy LB;Urošević S;Abramson LY;Jager-Hyman S;Nusslock R;Whitehouse WG;Hogan M
通讯作者：
Hogan M
影响因子：
10.6
作者：
Balodis IM;Potenza MN
通讯作者：
Potenza MN
影响因子：
5.4
作者：
Berghorst, Lisa H.;Kumar, Poornima;Pizzagalli, Diego A.
通讯作者：
Pizzagalli, Diego A.
影响因子：
6.9
作者：
Baker, Travis E.;Castellanos-Ryan, Natalie;Conrod, Patricia
通讯作者：
Conrod, Patricia