Staphylococcus aureus Biofilm: Morphology, Genetics, Pathogenesis and Treatment Strategies.
Staphylococcus aureus Biofilm: Morphology, Genetics, Pathogenesis and Treatment Strategies.
复制标题
金黄色葡萄球菌生物膜：形态，遗传学，发病机理和治疗策略。
DOI：
10.3390/ijerph18147602
复制
发表时间：
2021-07-16
影响因子：
--
通讯作者：
Rahman A
中科院分区：
文献类型：
--
作者：
Idrees M;Sawant S;Karodia N;Rahman A
金黄色葡萄球菌是一种引起不同传染病的医院细菌，从皮肤和软组织感染到更严重和危及生命的感染，如败血症。金黄色葡萄球菌形成了一个复杂的细胞外聚合生物膜结构，为微菌落的形成、微菌落的维持和扩散后的无根细胞的再定殖提供了一个完全安全的功能环境。金黄色葡萄球菌生物膜保护细胞免受不利条件的影响，即温度变化、营养限制或剥夺和脱水，更重要的是，保护细胞免受抗菌药物的影响。由于细菌细胞周围存在生物膜，药物对金黄色葡萄球菌的渗透性较低或完全无法穿透，因此药物对金黄色葡萄球菌的部分或完全无效。其他因素，如逃避宿主先天免疫系统，基因进化和遗传物质交换导致的基因组可塑性和适应性等，也是导致抗菌药物无效的原因。抗生素耐受性的增加导致了抗菌素耐药性（AMR）的出现和上升，这是一个严重的问题，除了给全球经济造成巨大的经济损失外，还导致全球人类和动物的发病率和死亡率上升。本文综述了金黄色葡萄球菌生物膜形成的不同方面及其总体结构、个体生物膜成分、临床意义以及在发病机制和耐药中的作用。本文还讨论了金黄色葡萄球菌生物膜定性和定量研究中使用的不同技术以及抑制和根除金黄色葡萄球菌生物膜的各种策略。
Staphylococcus aureus is a nosocomial bacterium causing different infectious diseases, ranging from skin and soft tissue infections to more serious and life-threatening infections such as septicaemia. S. aureus forms a complex structure of extracellular polymeric biofilm that provides a fully secured and functional environment for the formation of microcolonies, their sustenance and recolonization of sessile cells after its dispersal. Staphylococcus aureus biofilm protects the cells against hostile conditions, i.e., changes in temperature, limitations or deprivation of nutrients and dehydration, and, more importantly, protects the cells against antibacterial drugs. Drugs are increasingly becoming partially or fully inactive against S. aureus as they are either less penetrable or totally impenetrable due to the presence of biofilms surrounding the bacterial cells. Other factors, such as evasion of innate host immune system, genome plasticity and adaptability through gene evolution and exchange of genetic material, also contribute to the ineffectiveness of antibacterial drugs. This increasing tolerance to antibiotics has contributed to the emergence and rise of antimicrobial resistance (AMR), a serious problem that has resulted in increased morbidity and mortality of human and animal populations globally, in addition to causing huge financial losses to the global economy. The purpose of this review is to highlight different aspects of S. aureus biofilm formation and its overall architecture, individual biofilm constituents, clinical implications and role in pathogenesis and drug resistance. The review also discusses different techniques used in the qualitative and quantitative investigation of S. aureus biofilm and various strategies that can be employed to inhibit and eradicate S. aureus biofilm.
登录
查看更多内容
影响因子：
3.2
作者：
Gomes LC;Moreira JM;Simões M;Melo LF;Mergulhão FJ
通讯作者：
Mergulhão FJ
影响因子：
4.4
作者：
Azmi, Kifaya;Qrei, Walaa;Abdeen, Ziad
通讯作者：
Abdeen, Ziad
影响因子：
5.2
作者：
Fontecha-Umana, Fabio;Guillermo Rios-Castillo, Abel;Juan Rodriguez-Jerez, Jose
通讯作者：
Juan Rodriguez-Jerez, Jose
微生物学中的原子力显微镜：对微生物细胞表面的新结构和功能见解。
影响因子：
6.4
作者：
Dufrêne YF
通讯作者：
Dufrêne YF
影响因子：
2.8
作者：
Corrigan, Rebecca M.;Rigby, David;Foster, Timothy J.
通讯作者：
Foster, Timothy J.