Antidiabetic Effect of Brain-Derived Neurotrophic Factor and Its Association with Inflammation in Type 2 Diabetes Mellitus.
Antidiabetic Effect of Brain-Derived Neurotrophic Factor and Its Association with Inflammation in Type 2 Diabetes Mellitus.
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DOI：
10.1155/2017/2823671
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发表时间：
2017
影响因子：
4.3
通讯作者：
Postula M
中科院分区：
文献类型：
--
作者：
Eyileten C;Kaplon-Cieslicka A;Mirowska-Guzel D;Malek L;Postula M
脑源性神经营养因子（BDNF）是一种神经营养因子，在中枢神经系统、全身或外周炎症性疾病如急性冠状动脉综合征和2型糖尿病（T2DM）中起重要作用。BDNF也在几种非神经元组织中表达，血小板是外周BDNF的主要来源。在此，我们综述了BDNF在2型糖尿病血小板反应性中的潜在作用及其与选定的炎症和血小板活化介质的关系。除此之外，我们关注脂肪细胞因子，如瘦素、脂联素和脂联素，它们被认为参与糖尿病患者的炎症和脂糖代谢，因为先前的研究表明脂肪细胞因子与BDNF之间的关系。我们还综述了BDNF的抗糖尿病作用及其与2型糖尿病循环炎症因子的关系。
Brain-derived neurotrophic factor (BDNF) is a neurotrophin, which plays an important role in the central nervous system, and systemic or peripheral inflammatory conditions, such as acute coronary syndrome and type 2 diabetes mellitus (T2DM). BDNF is also expressed in several nonneuronal tissues, and platelets are the major source of peripheral BDNF. Here, we reviewed the potential role of BDNF in platelet reactivity in T2DM and its association with selected inflammatory and platelet activation mediators. Besides that, we focused on adipocytokines such as leptin, resistin, and adiponectin which are considered to take part in inflammation and both lipid and glucose metabolism in diabetic patients as previous studies showed the relation between adipocytokines and BDNF. We also reviewed the evidences of the antidiabetic effect of BDNF and the association with circulating inflammatory cytokines in T2DM.
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影响因子：
5.4
作者：
Géral C;Angelova A;Lesieur S
通讯作者：
Lesieur S
影响因子：
10.2
作者：
Comitato R;Saba A;Turrini A;Arganini C;Virgili F
通讯作者：
Virgili F
影响因子：
3.1
作者：
Eyileten, Ceren;Zaremba, Malgorzata;Postula, Marek
通讯作者：
Postula, Marek
影响因子：
3
作者：
Cohen-Cory, Susana;Kidane, Adhanet H.;Shirkey, Nicole J.;Marshak, Sonya
通讯作者：
Marshak, Sonya
影响因子：
1.2
作者：
Aune, Ulrike Liisberg;Ruiz, Lauren;Kajimura, Shingo
通讯作者：
Kajimura, Shingo