Effect of Red Light-Emitting Diodes Irradiation on Hemoglobin for Potential Hypertension Treatment Based on Confocal Micro-Raman Spectroscopy.
Effect of Red Light-Emitting Diodes Irradiation on Hemoglobin for Potential Hypertension Treatment Based on Confocal Micro-Raman Spectroscopy.
复制标题
基于共焦显微拉曼光谱治疗潜在高血压的红光发光二极管照射对血红蛋白的影响
作者：
Qiu X;Huang H;Huang Z;Zhuang Z;Guo Z;Liu S
Red light-emitting diodes (LED) were used to irradiate the isolated hypertension hemoglobin (Hb) and Raman spectra difference was recorded using confocal micro-Raman spectroscopy. Differences were observed between the controlled and irradiated Hb by comparing the spectra records. The Raman spectrum at the 1399 cm−1 band decreased following prolonged LED irradiation. The intensity of the 1639 cm−1 band decreased dramatically in the first five minutes and then gradually increased in a time-dependent manner. This observation indicated that LED irradiation increased the ability of oxygen binding in Hb. The appearance of the heme aggregation band at 1399 cm−1, in addition to the oxygen marker band at 1639 cm−1, indicated that, in our study, 30 min of irradiation with 15.0 mW was suitable for inhibiting heme aggregation and enhancing the oxygen-carrying capacity of Hb. Principal component analysis showed a one-to-one relationship between irradiated Hb at different time points and the corresponding Raman spectra. Our approach could be used to analyze the hemoglobin from patients with confocal micro-Raman spectroscopy and is helpful for developing new nondrug hypertension therapy.
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DOI：
10.1016/1011-1344(94)07078-3
发表时间：
1995-03-01
影响因子：
5.4
作者：
KARU, T;PYATIBRAT, L;KALENDO, G
通讯作者：
KALENDO, G
DOI：
10.1016/j.saa.2011.03.048
发表时间：
2011-09-01
影响因子：
4.4
作者：
Casella, Michele;Lucotti, Andrea;Zerbi, Giuseppe
通讯作者：
Zerbi, Giuseppe
DOI：
10.1016/j.jphotobiol.2005.11.004
发表时间：
2006-03-01
影响因子：
5.4
作者：
Gulsoy, M;Ozer, GH;Ertan, C
通讯作者：
Ertan, C
影响因子：
15
作者：
Kim, YH;Jeong, DH;Osuka, A
通讯作者：
Osuka, A
影响因子：
3.5
作者：
Lipsic, E;van der Horst, ICC;Zijlstra, F
通讯作者：
Zijlstra, F