Detection of exocrine dysfunction by MRI in patients with early chronic pancreatitis.
Detection of exocrine dysfunction by MRI in patients with early chronic pancreatitis.
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DOI：
10.1007/s00261-016-0917-2
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发表时间：
2017-03
期刊：
影响因子：
--
通讯作者：
Sandrasegaran K
中科院分区：
文献类型：
--
作者：
Tirkes T;Fogel EL;Sherman S;Lin C;Swensson J;Akisik F;Sandrasegaran K
目的探讨胰腺T1加权成像对早期CP的诊断价值。回顾性分析了51例疑似CP患者，均行胰泌素增强磁共振胰胆管造影（S-MRCP）和胰管内分泌素刺激试验（IDST）。正常组29例，低碳酸氢盐组22例。在IDST期间记录Bicycle水平、总胰液量和排泄流速。由两名放射科医生在S-MRCP上记录胰腺信号强度比（SIR）、脂肪信号分数、胰腺造影结果和十二指肠充盈度。正常和低碳酸氢盐组之间胰腺与脾脏的信号强度比（SIRP/s）存在显著差异（p < 0.0001）。胰腺液碳酸氢盐水平与SIRP/s呈显著正相关（p < 0.0001）。SIRP/s为1.2时，检测胰腺外分泌功能障碍的灵敏度为77%，特异性为83%（AUC：0.89）。胰腺T1加权磁共振信号对于检测与外分泌功能障碍相关的实质异常具有较高的敏感性和特异性，因此有助于评估可疑的早期CP。
To determine if T1-weighted MR signal of the pancreas can be used to detect early CP. A retrospective analysis was performed on 51 suspected CP patients, who had both secretin-enhanced magnetic resonance cholangiopancreatography (S-MRCP) and an intraductal secretin stimulation test (IDST). There were 29 patients in normal and 22 patients in the low bicarbonate group. Bicarbonate level, total pancreatic juice volume, and excretory flow rate were recorded during IDST. Signal intensity ratio of pancreas (SIR), fat signal fraction, pancreatograms findings, and grade of duodenal filling were recorded on S-MRCP by two blinded radiologists. There was a significant difference in the signal intensity ratio of the pancreas to spleen (SIRp/s) between the normal and low bicarbonate groups (p < 0.0001). A significant positive correlation was found between pancreatic fluid bicarbonate level and SIRp/s (p < 0.0001). SIRp/s of 1.2 yielded sensitivity of 77% and specificity of 83% for detection of pancreatic exocrine dysfunction (AUC: 0.89). T1-weighted MR signal of the pancreas has a high sensitivity and specificity for the detection of parenchymal abnormalities related to exocrine dysfunction and can therefore be helpful in evaluation of suspected early CP.
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影响因子：
4.4
作者：
Balci, N. Cern;Alkaade, Samer;Burton, Frank R.
通讯作者：
Burton, Frank R.
影响因子：
9.8
作者：
Trikudanathan, Guru;Walker, Sidney P.;Freeman, Martin L.
通讯作者：
Freeman, Martin L.
DOI：
10.1002/jmri.1880050307
发表时间：
1995-05-01
期刊：
JMRI-JOURNAL OF MAGNETIC RESONANCE IMAGING
影响因子：
--
作者：
WINSTON, CB;MITCHELL, DG;EHRLICH, SM
通讯作者：
EHRLICH, SM
影响因子：
5.9
作者：
Bali, M;Sztantics, A;Matos, C
通讯作者：
Matos, C
DOI：
10.1002/jmri.1880050215
发表时间：
1995-03-01
期刊：
JMRI-JOURNAL OF MAGNETIC RESONANCE IMAGING
影响因子：
--
作者：
MITCHELL, DG;WINSTON, CB;EHRLICH, SM
通讯作者：
EHRLICH, SM