Ripples in macaque V1 and V4 are modulated by top-down visual attention.
Ripples in macaque V1 and V4 are modulated by top-down visual attention.
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DOI：
10.1073/pnas.2210698120
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发表时间：
2023-01-31
影响因子：
11.1
通讯作者：
中科院分区：
文献类型：
--
作者：
哺乳动物海马体的电活动中的短暂、高频率的事件，称为波纹，发生在睡眠和静止期间，并与记忆的形成有关。在海马体外的活动行为中，它们在多大程度上发生还不清楚。我们检测到波动的视觉区域V1和V4的猕猴在自上而下的空间注意。波动发生的频率与海马体中报告的频率没有什么不同。重要的是，涟漪率调制的注意线索的感受野，刺激的大小，并注意力集中的大小。此外，在出现涟漪的试验中，反应时间适度减少。尖波波纹（SWR）是高度同步的神经元活动事件。它们主要在离线状态下的海马体中观察到，如探索暂停，慢波睡眠和静止觉醒。SWR与记忆巩固、空间导航和空间决策有关。最近，有报道称，在视觉搜索，远程空间探索的一种形式，在猕猴海马体的SWR。然而，SWRs与多种形式的清醒意识和目标导向行为之间的关联尚不清楚。我们报告说，涟漪活动发生在猕猴视觉区V1和V4在集中的空间注意。涟漪的发生受到刺激特征的调制，通过对感受野的注意和注意焦点的大小来增加。在注意力线索的感受野，猴子的反应时间在检测行为相关的事件减少了涟漪。这些结果表明，涟漪活动不仅限于离线状态下的海马活动，而是在主动注意状态和警惕行为期间发生在新皮层中。
Short-lived, high-frequency episodes in the electrical activities of mammalian hippocampus, called ripples, occur during sleep and quiescence, and are linked to memory formation. To which extent they occur during active behaviors outside hippocampus is poorly understood. We detected ripples in visual areas V1 and V4 of macaque monkeys during top-down spatial attention. Ripples occurred at frequencies not dissimilar to rates reported in the hippocampus. Critically, the ripple rate was modulated by attention cued to the receptive field, by stimulus size, and by the size of the attentional focus. Moreover, reaction times were modestly reduced on trials where ripples occurred. Sharp-wave ripples (SWRs) are highly synchronous neuronal activity events. They have been predominantly observed in the hippocampus during offline states such as pause in exploration, slow-wave sleep, and quiescent wakefulness. SWRs have been linked to memory consolidation, spatial navigation, and spatial decision-making. Recently, SWRs have been reported during visual search, a form of remote spatial exploration, in macaque hippocampus. However, the association between SWRs and multiple forms of awake conscious and goal-directed behavior is unknown. We report that ripple activity occurs in macaque visual areas V1 and V4 during focused spatial attention. The occurrence of ripples is modulated by stimulus characteristics, increased by attention toward the receptive field, and by the size of the attentional focus. During attention cued to the receptive field, the monkey’s reaction time in detecting behaviorally relevant events was reduced by ripples. These results show that ripple activity is not limited to hippocampal activity during offline states, rather they occur in the neocortex during active attentive states and vigilance behaviors.
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影响因子：
25
作者：
Dupret, David;O'Neill, Joseph;Pleydell-Bouverie, Barty;Csicsvari, Jozsef
通讯作者：
Csicsvari, Jozsef
影响因子：
25
作者：
Fujisawa, Shigeyoshi;Amarasingham, Asohan;Buzsaki, Gyoergy
通讯作者：
Buzsaki, Gyoergy
影响因子：
25
作者：
Girardeau, Gabrielle;Benchenane, Karim;Zugaro, Michael B.
通讯作者：
Zugaro, Michael B.
影响因子：
2.9
作者：
BUZSAKI, G
通讯作者：
BUZSAKI, G
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y