Green Light Antinociceptive and Reversal of Thermal and Mechanical Hypersensitivity Effects Rely on Endogenous Opioid System Stimulation.
Green Light Antinociceptive and Reversal of Thermal and Mechanical Hypersensitivity Effects Rely on Endogenous Opioid System Stimulation.
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DOI：
10.1016/j.jpain.2021.05.006
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发表时间：
2021-12
期刊：
影响因子：
--
通讯作者：
Ibrahim MM
中科院分区：
文献类型：
--
作者：
Martin LF;Moutal A;Cheng K;Washington SM;Calligaro H;Goel V;Kranz T;Largent-Milnes TM;Khanna R;Patwardhan A;Ibrahim MM
光疗的益处表现在多种疾病中，包括抑郁症、昼夜节律紊乱和神经退行性疾病。对偏头痛和纤维肌痛患者的研究表明，绿色发光二极管（GLED）曝光提供了一种实用和安全的治疗方法来管理慢性疼痛。在啮齿类动物中，GLED逆转了与神经性疼痛相关的超敏反应。然而，关于GLED功效的潜在机制知之甚少。在这里，我们试图了解绿色光如何调节内源性阿片系统。我们首先表征了暴露于GLED如何刺激雄性大鼠中枢神经系统中β-内啡肽和脑啡肽原的释放。此外，通过单独编辑每个受体，我们发现μ-和δ-阿片受体是绿色光在幼稚大鼠和HIV诱导的周围神经病变模型中的抗伤害效应所必需的。我们研究了GLED如何增加痛阈，并探讨了其在逆转HIV相关神经病变模型中的超敏反应的潜力。通过行为和基因编辑方法，我们确定绿色光通过调节脊髓中的内源性阿片系统提供抗伤害感受。这项工作确定了一个以前未知的机制，GLED可以改善疼痛管理。这些结果的临床转化将促进无不良反应的创新疗法的发展。
Benefits of phototherapy were characterized in multiple diseases including depression, circadian rhythm disruptions, and neurodegeneration. Studies on migraine and fibromyalgia patients revealed that green light-emitting diodes (GLED) exposure provides a pragmatic and safe therapy to manage chronic pain. In rodents, GLED reversed hypersensitivity related to neuropathic pain. However, little is known about the underlying mechanisms of GLED efficacy. Here, we sought to understand how green light modulates the endogenous opioid system. We first characterized how exposure to GLED stimulates release of β-endorphin and proenkephalin in the central nervous system of male rats. Moreover, by individually editing each of the receptors, we found that μ- and δ-opioid receptors are required for green light’s antinociceptive effect in naïve rats and a model of HIV-induced peripheral neuropathy. We investigated how GLED could increase pain thresholds, and explored its potential in reversing hypersensitivity in a model of HIV-related neuropathy. Through behavioral and gene editing approaches, we identified that green light provides antinociception via modulation of the endogenous opioid system in the spinal cord. This work identifies a previously unknown mechanism by which GLED can improve pain management. Clinical translation of these results will advance the development of an innovative therapy devoid of adverse effects.
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影响因子：
46.9
作者：
Heck, Dirk;Kowalczyk, Monika S.;Yudovich, David;Belizaire, Roger;Puram, Rishi V.;McConkey, Marie E.;Thielke, Anne;Aster, Jon C.;Regev, Aviv;Ebert, Benjamin L.
通讯作者：
Ebert, Benjamin L.
影响因子：
2.8
作者：
Green, A.;Cohen-Zion, M.;Dagan, Y.
通讯作者：
Dagan, Y.
影响因子：
16.2
作者：
Bardoni R;Tawfik VL;Wang D;François A;Solorzano C;Shuster SA;Choudhury P;Betelli C;Cassidy C;Smith K;de Nooij JC;Mennicken F;O'Donnell D;Kieffer BL;Woodbury CJ;Basbaum AI;MacDermott AB;Scherrer G
通讯作者：
Scherrer G
影响因子：
2.2
作者：
Holden, Janean E.;Jeong, Younhee;Forrest, Jeannine M.
通讯作者：
Forrest, Jeannine M.
影响因子：
3.7
作者：
Rocha FA;Gomes BD;Silveira LC;Martins SL;Aguiar RG;de Souza JM;Ventura DF
通讯作者：
Ventura DF