Sphingolipids in the Heart: From Cradle to Grave.
Sphingolipids in the Heart: From Cradle to Grave.
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DOI：
10.3389/fendo.2020.00652
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发表时间：
2020
影响因子：
5.2
通讯作者：
Cowart LA
中科院分区：
文献类型：
--
作者：
Kovilakath A;Jamil M;Cowart LA
心血管疾病是全球死亡的主要原因，这在很大程度上是由近几十年来代谢疾病的增加所驱动的。代谢性疾病改变了多个器官和组织中鞘脂的代谢、分布和特征;因此，鞘脂代谢和信号传导作为肥胖症（包括心血管疾病）各种病理结局中代谢病理生理学的贡献者已被大力研究。许多实验证据表明，靶向鞘脂代谢在心脏代谢疾病的背景下可能是有利的。然而，心脏是一个结构和功能复杂的器官，其中生物活性鞘脂已被证明不仅介导病理过程，而且有助于心脏发生和心脏功能中的基本功能。此外，一些鞘脂在缺血/再灌注损伤的情况下具有保护作用。除了机制的贡献，近年来使用的非靶向脂质组学方法已经确定了一些特定的循环鞘脂作为心血管疾病背景下的新型生物标志物。在这篇综述中，我们总结了最近的文献中有害和有益的贡献，鞘脂对心脏发生和心肌功能，以及最近确定的新的鞘脂生物标志物的心血管疾病的风险预测和诊断。
Cardiovascular diseases are the leading cause of mortality worldwide and this has largely been driven by the increase in metabolic disease in recent decades. Metabolic disease alters metabolism, distribution, and profiles of sphingolipids in multiple organs and tissues; as such, sphingolipid metabolism and signaling have been vigorously studied as contributors to metabolic pathophysiology in various pathological outcomes of obesity, including cardiovascular disease. Much experimental evidence suggests that targeting sphingolipid metabolism may be advantageous in the context of cardiometabolic disease. The heart, however, is a structurally and functionally complex organ where bioactive sphingolipids have been shown not only to mediate pathological processes, but also to contribute to essential functions in cardiogenesis and cardiac function. Additionally, some sphingolipids are protective in the context of ischemia/reperfusion injury. In addition to mechanistic contributions, untargeted lipidomics approaches used in recent years have identified some specific circulating sphingolipids as novel biomarkers in the context of cardiovascular disease. In this review, we summarize recent literature on both deleterious and beneficial contributions of sphingolipids to cardiogenesis and myocardial function as well as recent identification of novel sphingolipid biomarkers for cardiovascular disease risk prediction and diagnosis.
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鞘氨醇激酶和1-磷酸盐受体：心血管系统中的信号传导和作用。
影响因子：
5.6
作者：
Cannavo A;Liccardo D;Komici K;Corbi G;de Lucia C;Femminella GD;Elia A;Bencivenga L;Ferrara N;Koch WJ;Paolocci N;Rengo G
通讯作者：
Rengo G
影响因子：
5
作者：
Adamy, Christophe;Mulder, Paul;Pecker, Francoise
通讯作者：
Pecker, Francoise
DOI：
10.1007/978-1-4614-0650-1_3
发表时间：
2011-01-01
期刊：
SPHINGOLIPIDS AND METABOLIC DISEASE
影响因子：
--
作者：
Baranowski, Marcin;Gorski, Jan
通讯作者：
Gorski, Jan
影响因子：
4.6
作者：
Bhat, Owais M.;Li, Guangbi;Li, Pin-Lan
通讯作者：
Li, Pin-Lan
DOI：
10.1007/5584_2017_105
发表时间：
2018-01-01
期刊：
HEART FAILURE: FROM RESEARCH TO CLINICAL PRACTICE, VOL 3
影响因子：
--
作者：
Alonso, Nuria;Moliner, Pedro;Mauricio, Didac
通讯作者：
Mauricio, Didac