Functional Neural Networks in Writer's Cramp as Determined by Graph-Theoretical Analysis.
Functional Neural Networks in Writer's Cramp as Determined by Graph-Theoretical Analysis.
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DOI：
10.3389/fneur.2021.744503
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发表时间：
2021
影响因子：
3.4
通讯作者：
Witt K
中科院分区：
文献类型：
--
作者：
Schill J;Zeuner KE;Knutzen A;Tödt I;Simonyan K;Witt K
肌张力障碍是一种使人衰弱的神经运动障碍，其特征在于不自主的肌肉收缩，并且由复杂的病理生理学发展而来。图论分析方法已被用来研究不同形式的肌张力障碍患者的功能网络变化。在这项研究中，我们的目的是描述书写痉挛（一种局灶性手肌张力障碍）背后的异常大脑连接。为此，我们研究了功能性磁共振扫描20名书写痉挛患者（11名女性/9名男性）和26名健康对照（10名女性/16名男性）执行顺序手指敲击任务与他们的非优势（和患者非肌张力障碍）的手。功能连接矩阵用于确定组平均脑网络。我们的数据表明，在他们的神经元网络中，书写痉挛患者招募了更少的功能更分离的区域。然而，这并没有影响网络的信息传输效率。中枢分析揭示了初级运动皮层、丘脑和小脑的通信模式的改变。由于我们没有观察到组间运动结果的任何差异，我们假设这些网络变化构成了患者网络内的代偿性重新路由。在二次分析中，我们比较了简单的书写痉挛患者（仅在书写时影响手）和复杂的书写痉挛患者（在其他精细运动任务中也影响手）。我们在简单书写痉挛组中发现了异常的小脑连接，而在复杂书写痉挛组中这种情况不那么明显。我们的初步研究结果表明，纵向研究有关小脑连接在WC进展可以提供洞察力WC的早期代偿机制。
Dystonia, a debilitating neurological movement disorder, is characterized by involuntary muscle contractions and develops from a complex pathophysiology. Graph theoretical analysis approaches have been employed to investigate functional network changes in patients with different forms of dystonia. In this study, we aimed to characterize the abnormal brain connectivity underlying writer's cramp, a focal hand dystonia. To this end, we examined functional magnetic resonance scans of 20 writer's cramp patients (11 females/nine males) and 26 healthy controls (10 females/16 males) performing a sequential finger tapping task with their non-dominant (and for patients non-dystonic) hand. Functional connectivity matrices were used to determine group averaged brain networks. Our data suggest that in their neuronal network writer's cramp patients recruited fewer regions that were functionally more segregated. However, this did not impair the network's efficiency for information transfer. A hub analysis revealed alterations in communication patterns of the primary motor cortex, the thalamus and the cerebellum. As we did not observe any differences in motor outcome between groups, we assume that these network changes constitute compensatory rerouting within the patient network. In a secondary analysis, we compared patients with simple writer's cramp (only affecting the hand while writing) and those with complex writer's cramp (affecting the hand also during other fine motor tasks). We found abnormal cerebellar connectivity in the simple writer's cramp group, which was less prominent in complex writer's cramp. Our preliminary findings suggest that longitudinal research concerning cerebellar connectivity during WC progression could provide insight on early compensatory mechanisms in WC.
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影响因子：
8.6
作者：
Albanese, Alberto;Bhatia, Kailash;Bressman, Susan B.;DeLong, Mahlon R.;Fahn, Stanley;Fung, Victor S. C.;Hallett, Mark;Jankovic, Joseph;Jinnah, Hyder A.;Klein, Christine;Lang, Anthony E.;Mink, Jonathan W.;Teller, Jan K.
通讯作者：
Teller, Jan K.
影响因子：
4.2
作者：
Gallea, C.;Balas, M.;Lehericy, S.
通讯作者：
Lehericy, S.
影响因子：
4.1
作者：
Das, Chandi Prasad;Prabhakar, Sudesh;Truong, Daniel
通讯作者：
Truong, Daniel
影响因子：
8.6
作者：
Fuertinger, Stefan;Simonyan, Kristina
通讯作者：
Simonyan, Kristina
影响因子：
5.3
作者：
Lynall, Mary-Ellen;Bassett, Danielle S.;Bullmore, Edward T.
通讯作者：
Bullmore, Edward T.