Problem behaviour in adolescent boys with fragile X syndrome: relative prevalence, frequency and severity.
Problem behaviour in adolescent boys with fragile X syndrome: relative prevalence, frequency and severity.
复制标题
患有脆弱X综合征的青春期男孩的问题行为：相对患病率，频率和严重程度。
DOI：
10.1111/jir.12341
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发表时间：
2016-12
期刊：
影响因子：
--
通讯作者：
Hustyi KM
中科院分区：
文献类型：
--
作者：
Hall SS;Barnett RP;Hustyi KM
脆性X染色体综合征是已知的最常见的遗传性智力残疾形式，很大一部分患有这种疾病的男孩表现出问题行为（例如攻击、自残、破坏财产和陈规定型观念），可能对他人以及有关个人的健康和安全产生负面影响。然而，与同样表现出问题行为的混合病因性ID男孩相比，FXS男孩表现出问题行为的相对患病率、频率和严重程度方面的数据有限。作为一项更大的问题行为研究的一部分，我们获得了85名患有FXS的青春期男孩和155名年龄匹配的混合病因性ID男孩的调查数据，这些男孩至少表现出一种形式的问题行为。FXS男孩的刻板印象发生率高于混合病因型男孩（χ2 = 4.52, P = 0.012），自伤发生率高于混合病因型男孩（U = 2525, P = 0.010），攻击行为发生率低于混合病因型男孩（U = 4176, P = 0.029）。在每一组中，攻击和财产破坏的评级在频率和严重程度上都高度相关（r = 0.60至0.71）。根据年龄对数据进行检验，FXS男孩自伤相对频率随年龄的增长而降低（χ2 = 8.29, P = 0.040）。综上所述，这些结果完善和扩展了先前关于FXS行为表型特异性的研究，并表明FXS男孩表现出的特定形式的问题行为在患病率、频率和严重程度方面似乎与混合病因性ID男孩表现出的问题行为不同。需要采用更客观的测量频率和严重程度的研究，包括直接观察，来证实这些发现。
A large proportion of boys with fragile X syndrome (FXS), the most common known inherited form of intellectual disability (ID), exhibit problem behaviours (e.g. aggression, self-injury, property destruction and stereotypy) that can negatively impact the health and safety of others as well as the individual concerned. However, data are limited concerning the relative prevalence, frequency and severity of problem behaviours exhibited by boys with FXS compared with those by boys with mixed-aetiology ID who also exhibit problem behaviours. As part of a larger study on problem behaviour, we obtained survey data on 85 adolescent boys with FXS and 155 age-matched boys with mixed-aetiology ID who exhibited at least one form of problem behaviour. For boys with FXS, stereotypy was reported to be more prevalent (χ2 = 4.52, P = 0.012), self-injury was reported to more frequent (U = 2525, P = 0.010) and aggression was reported to be less severe (U = 4176, P = 0.029) than for boys with mixed-aetiology ID. Ratings of aggression and property destruction were highly correlated in each group in terms of both frequency and severity (r = 0.60 to 0.71). Examination of the data by age indicated that the relative frequency of self-injury decreased with age in boys with FXS (χ2 = 8.29, P = 0.040). Taken together, these results refine and extend previous studies concerning the specificity of the behavioural phenotype in FXS and indicate that specific forms of problem behaviour shown by boys with FXS appear to differ from those exhibited by boys with mixed-aetiology ID in terms of prevalence, frequency and severity. Studies employing more objective measures of frequency and severity, including direct observations, are needed to confirm these findings.
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DOI：
10.1111/j.1365-2788.2010.01337.x
发表时间：
2011-02-01
影响因子：
3.6
作者：
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