Red notoginseng: higher ginsenoside content and stronger anticancer potential than Asian and American ginseng.
Red notoginseng: higher ginsenoside content and stronger anticancer potential than Asian and American ginseng.
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DOI：
10.1016/j.foodchem.2010.10.049
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发表时间：
2011-04-15
期刊：
影响因子：
8.8
通讯作者：
Yuan, Chun-Su
中科院分区：
文献类型：
--
作者：
Sun, Shi;Qi, Lian-Wen;Du, Guang-Jian;Mehendale, Sangeeta R.;Wang, Chong-Zhi;Yuan, Chun-Su
对三七（NG，Panax notoginseng）、亚洲人参（AG，P. ginseng）和西洋参（AmG，P. quinquefolius）的白色（风干）和红色（蒸制）根的皂苷和抗癌活性进行了系统比较。通过HPLC-UV在202 nm处同时定量19种主要人参皂苷，对不同人参品种的化学特征进行了表征。用MTS法和流式细胞仪分别检测其对人大肠癌细胞的抗增殖和促凋亡作用。化学分析表明，白色NG具有最丰富的皂苷，即，比白色AmG和AG高2倍和5倍。在蒸煮过程中，观察到白色人参中的原始极性人参皂苷向红参中新的、极性较小的降解化合物的广泛转化。白色人参产生弱的抗增殖作用，而红参表现出抗增殖和促凋亡作用的显著增加（均P < 0.01，与白色人参相比）。在三种红参中，红参NG的抗肿瘤活性最好。由于NG成本低，红NG具有较高的生物活性，因此红NG有望成为一种有效的肿瘤化学预防植物产品。
A systematic comparison of the ginsenosides and anticancer activities was performed among white (air-dried) and red (steamed) roots of notoginseng (NG, Panax notoginseng), Asian ginseng (AG, P. ginseng), and American ginseng (AmG, P. quinquefolius). Chemical profiles of different ginseng species were characterized, through simultaneous quantification of nineteen major ginsenosides, by HPLC-UV at 202 nm. The antiproliferative and pro-apoptotic effects on human colorectal cancer cells were determined by MTS method and flow cytometry, respectively. Chemical analysis indicated that white NG possessed the most abundant ginsenosides, i.e., two- and five-fold higher than white AmG and AG. During the steaming process, extensive conversion of the original polar ginsenosides in white ginseng to new, less polar, degradation compounds in red ginseng was observed. White ginsengs produced weak antiproliferative effects, while red ginsengs exhibited a significant increase in antiproliferative and pro-apoptotic effects (both P < 0.01 vs. white ginseng). Among the three red ginsengs, red NG showed the best anticancer activity. Due to the low cost of NG and high bioactivity of red NG, the red NG is promising to be a useful botanical product in cancer chemoprevention.
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影响因子：
7.4
作者：
Li, WK;Gu, CG;van Breemen, RB
通讯作者：
van Breemen, RB
影响因子：
8.8
作者：
Chen, C. -Y. Oliver;Ribaya-Mercado, Judy D.;Blumberg, Jeffrey B.
通讯作者：
Blumberg, Jeffrey B.
影响因子：
5.4
作者：
Kang, Ki Sung;Yamabe, Noriko;Yokozawa, Takako
通讯作者：
Yokozawa, Takako
利用 HPLC-ELSD 同时定量从三七中提取的黑参中的 19 种人参皂苷
DOI：
10.1016/j.jpba.2009.03.025
发表时间：
2009-08-15
影响因子：
3.4
作者：
Sun, Bai-Shen;Gu, Li-Juan;Sung, Chang-Keun
通讯作者：
Sung, Chang-Keun
影响因子：
7.4
作者：
Chan, TWD;But, PPH;Xu, HX
通讯作者：
Xu, HX