Prenatal exposure to perfluorooctanoate and risk of overweight at 20 years of age: a prospective cohort study.
Prenatal exposure to perfluorooctanoate and risk of overweight at 20 years of age: a prospective cohort study.
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产前暴露于全氟辛酸和20岁时超重的风险：一项前瞻性队列研究。
DOI：
10.1289/ehp.1104034
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发表时间：
2012-05
影响因子：
10.4
通讯作者：
Olsen SF
中科院分区：
文献类型：
--
作者：
Halldorsson TI;Rytter D;Haug LS;Bech BH;Danielsen I;Becher G;Henriksen TB;Olsen SF
背景：全氟烷基酸是在各种工业应用中使用的持久性化合物。在这些化合物中，目前在世界各地的人体中检测到全氟辛酸盐（PFOA）。最近一项关于小鼠低剂量PFOA发育暴露的研究报告称，青春期后雌性后代体重增加，肥胖生物标志物升高。目的：研究青春期后雌性小鼠体重增加的结果是否可以在人类中复制。方法：在1988-1989年招募了665名丹麦孕妇，并对后代进行了20年的随访。从妊娠第30周开始测定血清中PFOA含量。在随访中记录后代体重指数（BMI）和腰围（n = 665），并对一部分参与者（n = 422）的肥胖生物标志物进行量化。结果：在调整协变量后，包括母亲孕前BMI、吸烟、受教育程度和出生体重，子宫内接触PFOA与女性后代20岁时的人体测量呈正相关，而与男性后代无关。母亲PFOA浓度最高和最低四分位数（中位数：5.8 vs 2.3 ng/mL）的校正相对危险度比较，超重或肥胖（BMI≥25 kg/m2）的女性后代的校正相对危险度为3.1[95%可信区间（CI）： 1.4, 6.9]，腰围为> 88 cm的女性后代的校正相对危险度为3.0 （95% CI: 1.3, 6.8）。这对应于平均BMI和腰围分别增加1.6 kg/m2 （95% CI: 0.6, 2.6）和4.3 cm （95% CI: 1.4, 7.3）。此外，母体PFOA浓度与雌性后代血清胰岛素和瘦素水平呈正相关，与脂联素水平呈负相关。在男性中也观察到类似的关联，尽管由于观察较少，点估计不太精确。母亲的全氟辛烷磺酸（PFOS）、全氟辛烷磺酰胺（PFOSA）和全氟壬酸盐（PFNA）浓度与子女20岁时的人体测量值没有独立关联。结论：我们关于低剂量PFOA发育暴露影响的研究结果与实验结果一致，表明雌性后代在20岁时具有致肥作用。
Background: Perfluoroalkyl acids are persistent compounds used in various industrial -applications. Of these compounds, perfluorooctanoate (PFOA) is currently detected in humans worldwide. A recent study on low-dose developmental exposure to PFOA in mice reported increased weight and elevated biomarkers of adiposity in postpubertal female offspring. Objective: We examined whether the findings of increased weight in postpubertal female mice could be replicated in humans. Methods: A prospective cohort of 665 Danish pregnant women was recruited in 1988–1989 with offspring follow-up at 20 years. PFOA was measured in serum from gestational week 30. Offspring body mass index (BMI) and waist circumference were recorded at follow-up (n = 665), and biomarkers of adiposity were quantified in a subset (n = 422) of participants. Results: After adjusting for covariates, including maternal pre-pregnancy BMI, smoking, education, and birth weight, in utero exposure to PFOA was positively associated with anthropometry at 20 years in female but not male offspring. Adjusted relative risks comparing the highest with lowest quartile (median: 5.8 vs. 2.3 ng/mL) of maternal PFOA concentration were 3.1 [95% confidence interval (CI): 1.4, 6.9] for overweight or obese (BMI ≥ 25 kg/m2) and 3.0 (95% CI: 1.3, 6.8) for waist circumference > 88 cm among female offspring. This corresponded to estimated increases of 1.6 kg/m2 (95% CI: 0.6, 2.6) and 4.3 cm (95% CI: 1.4, 7.3) in average BMI and waist circumference, respectively. In addition, maternal PFOA concentrations were positively associated with serum insulin and leptin levels and inversely associated with adiponectin levels in female offspring. Similar associations were observed for males, although point estimates were less precise because of fewer observations. Maternal perfluorooctane sulfonate (PFOS), perfluorooctane sulfonamide (PFOSA), and perfluorononanoate (PFNA) concentrations were not independently associated with offspring anthropometry at 20 years. Conclusions: Our findings on the effects of low-dose developmental exposures to PFOA are in line with experimental results suggesting obesogenic effects in female offspring at 20 years of age.
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3.8
作者：
Macon, Madisa B.;Villanueva, LaTonya R.;Fenton, Suzanne E.
通讯作者：
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