Engineering Yarrowia lipolytica to produce nutritional fatty acids: Current status and future perspectives.
Engineering Yarrowia lipolytica to produce nutritional fatty acids: Current status and future perspectives.
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DOI：
10.1016/j.synbio.2022.06.002
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发表时间：
2022-12
影响因子：
4.8
通讯作者：
Ji, Xiao-Jun
中科院分区：
文献类型：
--
作者：
Cao, Lizhen;Yin, Mingxue;Shi, Tian-Qiong;Lin, Lu;Ledesma-Amaro, Rodrigo;Ji, Xiao-Jun
关键词：
由于其重要的生理功能，营养脂肪酸作为营养食品补充剂具有很大的潜力，用于预防一系列疾病，如炎症，抑郁症，关节炎，骨质疏松症，糖尿病和癌症。微生物生物合成脂肪酸顺应了可持续发展的潮流，实现了绿色、环保、高效的生产。解脂耶氏酵母作为一种天然产油酵母，特别适合于脂肪酸的生产。此外，它拥有各种基因工程工具和新颖的代谢工程策略，使其成为生产一系列增值产品的强大主力。本文综述了近年来Y.解脂剂，包括共轭脂肪酸和多不饱和脂肪酸。并对利用Y. lipolytica平台进行了讨论，在目前的进展，挑战和趋势，在这一领域。最后，也强调了未来研究的指导方针。
Due to their vital physiological functions, nutritional fatty acids have great potential as nutraceutical food supplements for preventing an array of diseases such as inflammation, depression, arthritis, osteoporosis, diabetes and cancer. Microbial biosynthesis of fatty acids follows the trend of sustainable development, as it enables green, environmentally friendly and efficient production. As a natural oleaginous yeast, Yarrowia lipolytica is especially well-suited for the production of fatty acids. Moreover, it has a variety of genetic engineering tools and novel metabolic engineering strategies that make it a robust workhorse for the production of an array of value-added products. In this review, we summarize recent advances in metabolic engineering strategies for accumulating nutritional fatty acids in Y. lipolytica, including conjugated fatty acids and polyunsaturated fatty acids. In addition, the future prospects of nutritional fatty acid production using the Y. lipolytica platform are discussed in light of the current progress, challenges, and trends in this field. Finally, guidelines for future studies are also emphasized.
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DOI：
10.1073/pnas.0511079103
发表时间：
2006-06-20
影响因子：
11.1
作者：
Damude, Howard G.;Zhang, Hongxiang;Yadav, Narendra S.
通讯作者：
Yadav, Narendra S.
影响因子：
64.8
作者：
Dujon, B;Sherman, D;Souciet, JL
通讯作者：
Souciet, JL
影响因子：
5
作者：
Cordova, Lauren T.;Alper, Hal S.
通讯作者：
Alper, Hal S.
影响因子：
5
作者：
Cordova, Lauren T.;Palmer, Claire M.;Alper, Hal S.
通讯作者：
Alper, Hal S.
影响因子：
4.1
作者：
Goh, Kah K.;Chen, Cynthia Yi-An;Lu, Mong-Liang
通讯作者：
Lu, Mong-Liang