Responses and functions of dopamine in nucleus accumbens core during social behaviors.
Responses and functions of dopamine in nucleus accumbens core during social behaviors.
复制标题
伏隔核多巴胺在社会行为过程中的反应和功能
DOI：
10.1016/j.celrep.2022.111246
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发表时间：
2022-08-23
期刊：
影响因子：
8.8
通讯作者：
Lin, Dayu
中科院分区：
文献类型：
--
作者：
Dai, Bing;Sun, Fangmia;Tong, Xiaoyu;Ding, Yizhuo;Kuang, Amy;Osakada, Takuya;Li, Yulong;Lin, Dayu
社会行为是最重要的动机行为之一。多巴胺（DA），一种“奖励”信号，如何在社会行为中释放，几十年来一直是人们感兴趣的话题。在这里，我们使用一个遗传编码的DA传感器，GRABDA2m，记录DA活动的核脑桥（NAc）的核心在各种社会行为的男性和女性小鼠。我们发现，DA释放在接近，调查和完善阶段的社会行为的信号动物的动机，熟悉的社会目标，和效价的经验，分别。积极和消极的社会经验会引发相反的DA模式。此外，DA释放在交配和战斗中的性别二态性与男性比女性更高的水平。在功能水平上，NAc中DA的增加增强了对熟悉同种的社会兴趣，并消除了失败引起的社会回避。总之，我们的研究结果揭示了复杂的信息编码的NAc DA活动在社会行为和他们的多级功能的作用。Dai等人报道了在小鼠的各种社会行为期间，中脑核（NAc）核心中复杂的和性二态的DA释放。在社会行为的接近、调查和行动阶段，DA释放携带不同的信息。当DA的释放被人为地提高时，它会增强社会兴趣，减少失败引起的社会回避。
Social behaviors are among the most important motivated behaviors. How dopamine (DA), a “reward” signal, releases during social behaviors has been a topic of interest for decades. Here, we use a genetically encoded DA sensor, GRABDA2m, to record DA activity in the nucleus accumbens (NAc) core during various social behaviors in male and female mice. We find that DA releases during approach, investigation and consummation phases of social behaviors signal animals’ motivation, familiarity of the social target, and valence of the experience, respectively. Positive and negative social experiences evoke opposite DA patterns. Furthermore, DA releases during mating and fighting are sexually dimorphic with a higher level in males than in females. At the functional level, increasing DA in NAc enhances social interest toward a familiar conspecific and alleviates defeat-induced social avoidance. Altogether, our results reveal complex information encoded by NAc DA activity during social behaviors and their multistage functional roles. Dai et al. report complex and sexually dimorphic DA release in nucleus accumbens (NAc) core during various social behaviors in mice. DA release during approach, investigation, and action phases of social behaviors carries distinct information. When DA release is artificially boosted, it enhances social interest and reduces defeat-induced social avoidance.
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DOI：
10.1073/pnas.1014269108
发表时间：
2011-09-13
影响因子：
11.1
作者：
Glimcher, Paul W.
通讯作者：
Glimcher, Paul W.
影响因子：
1.9
作者：
Gabor, Christopher S.;Phan, Anna;Choleris, Elena
通讯作者：
Choleris, Elena
影响因子：
3.3
作者：
通讯作者：
--
影响因子：
25
作者：
Falkner AL;Grosenick L;Davidson TJ;Deisseroth K;Lin D
通讯作者：
Lin D
影响因子：
16.2
作者：
Bromberg-Martin, Ethan S.;Matsumoto, Masayuki;Hikosaka, Okihide
通讯作者：
Hikosaka, Okihide