Alpha-adrenergic receptor gene polymorphisms and cardiovascular reactivity to stress in Black adolescents and young adults.
Alpha-adrenergic receptor gene polymorphisms and cardiovascular reactivity to stress in Black adolescents and young adults.
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DOI：
10.1111/j.1469-8986.2011.01319.x
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发表时间：
2012-03
期刊：
影响因子：
3.7
通讯作者：
Quasney MW
中科院分区：
文献类型：
--
作者：
Kelsey RM;Alpert BS;Dahmer MK;Krushkal J;Quasney MW
心血管对应激的反应性和α-肾上腺素能受体（α-AR）功能可能参与高血压的发生发展。由于美国黑人患高血压的风险增加，我们在500名血压正常的黑人青年中评估了α1A-AR（Arg 492 Cys）、α2A-AR（− 1291 C/G）和α2B-AR（Ins/Del 301 -303）基因变异与心血管反应性之间的关联。心率，射血前期，总外周阻力，血压在寒冷和心理应激。α1A-AR基因Arg 492 Cys多态性与心率应激反应性相关，但这种相关性依赖于性别。α2A-AR基因的− 1291 C/G启动子多态性与血管对应激的反应性相关;血管收缩增加是变异G等位基因拷贝数的线性函数。因此，在年轻黑人中，α-AR的遗传变异与心血管反应性之间出现了特定的关联。
Cardiovascular reactivity to stress and α-adrenergic receptor (α-AR) function may contribute to the development of hypertension. As Black Americans have an increased risk of hypertension, we evaluated associations between α1A-AR (Arg492Cys), α2A-AR (−1291C/G), and α2B-AR (Ins/Del301-303) gene variants and cardiovascular reactivity in 500 normotensive Black youth. Heart rate, preejection period, total peripheral resistance, and blood pressure were measured during cold and psychological stress. The Arg492Cys polymorphism in the α1A-AR gene was associated with heart rate reactivity to stress, but the association depended on sex. The −1291C/G promoter polymorphism in the α2A-AR gene was associated with vascular reactivity to stress; vasoconstriction increased as a linear function of the number of copies of the variant G allele. Thus, specific associations emerged between genetic variations in α-ARs and cardiovascular reactivity in young Blacks.
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影响因子：
3
作者：
Iacoviello, Massimo;Forleo, Cinzia;Pitzalis, Maria Vittoria
通讯作者：
Pitzalis, Maria Vittoria
影响因子：
64.8
作者：
Hein, L;Altman, JD;Kobilka, BK
通讯作者：
Kobilka, BK
影响因子：
20.1
作者：
FREEDMAN, RR;SABHARWAL, SC;DESAI, N
通讯作者：
DESAI, N
影响因子：
3.7
作者：
Bouma, Esther M. C.;Riese, Harriette;Oldehinkel, Albertine J.
通讯作者：
Oldehinkel, Albertine J.
影响因子：
5.7
作者：
Garenc, C;Pérusse, L;Bouchard, C
通讯作者：
Bouchard, C