Multivariate associations between behavioural dimensions and white matter across children and adolescents with and without attention-deficit/hyperactivity disorder.
Multivariate associations between behavioural dimensions and white matter across children and adolescents with and without attention-deficit/hyperactivity disorder.
复制标题
在有或没有注意力缺陷/多动症的儿童和青少年之间行为维度与白质之间的多元关联。
DOI：
10.1111/jcpp.13689
复制
发表时间：
2023-02
影响因子：
7.6
通讯作者：
Huang, Xiaoqi
中科院分区：
文献类型：
--
作者：
Bu, Xuan;Gao, Yingxue;Liang, Kaili;Bao, Weijie;Chen, Ying;Guo, Lanting;Gong, Qiyong;Lu, Hanzhang;Caffo, Brian;Mori, Susumu;Huang, Xiaoqi
注意缺陷多动障碍(ADHD)是一种异质性神经发育障碍。脑白质微结构的完整性在ADHD表现的神经机制中起着关键作用。然而，特定的行为维度和白质微结构之间的关系却不那么为人所知。这项研究的目的是使用数据驱动的多变量方法，在患有和不患有ADHD的儿童和青少年中确定白质与广泛的临床特征之间的联系。我们招募了130名儿童(62名对照组和68名ADHD)，并采用正则化的广义典型相关分析来表征白质与涵盖症状、认知和行为三个领域的一套全面的临床指标之间的关联。我们进一步应用线性判别分析来整合这些关联，以探索潜在的发育效应。我们在每个领域描绘了两个大脑行为维度的关联，导致了与多动有关的总共六种白质微结构变化的多变量模式-冲动和轻度受影响；执行功能和工作记忆；外化行为和社交退缩。除了执行功能和外化行为具有相似的白质模式外，所有其他维度都与白质微结构变化的特定模式有关。ADHD组多维联想得分随年龄增长总体呈上升趋势并趋于正常化，而对照组则保持稳定。我们发现ADHD和对照组之间存在多变量神经行为关联，这表明多种白质模式是ADHD异质性的基础，并为更准确的诊断和个性化治疗提供神经基础。
Attention deficit/hyperactivity disorder (ADHD) is a heterogeneous neurodevelopmental disorder. Integrity of white matter microstructure plays a key role in the neural mechanism of ADHD presentations. However, the relationships between specific behavioural dimensions and white matter microstructure are less well known. This study aimed to identify associations between white matter and a broad set of clinical features across children and adolescent with and without ADHD using a data‐driven multivariate approach. We recruited a total of 130 children (62 controls and 68 ADHD) and employed regularized generalized canonical correlation analysis to characterize the associations between white matter and a comprehensive set of clinical measures covering three domains, including symptom, cognition and behaviour. We further applied linear discriminant analysis to integrate these associations to explore potential developmental effects. We delineated two brain–behaviour dimensional associations in each domain resulting a total of six multivariate patterns of white matter microstructural alterations linked to hyperactivity–impulsivity and mild affected; executive functions and working memory; externalizing behaviour and social withdrawal, respectively. Apart from executive function and externalizing behaviour sharing similar white matter patterns, all other dimensions linked to a specific pattern of white matter microstructural alterations. The multivariate dimensional association scores showed an overall increase and normalization with age in ADHD group while remained stable in controls. We found multivariate neurobehavioral associations exist across ADHD and controls, which suggested that multiple white matter patterns underlie ADHD heterogeneity and provided neural bases for more precise diagnosis and individualized treatment.
登录
查看更多内容
探索患有注意力缺陷/多动症的儿童的白质功能网络。
影响因子：
4.8
作者：
Bu X;Liang K;Lin Q;Gao Y;Qian A;Chen H;Chen W;Wang M;Yang C;Huang X
通讯作者：
Huang X
影响因子：
24.8
作者：
Qiu A;Mori S;Miller MI
通讯作者：
Miller MI
重度抑郁症的皮质结构差异与细胞类型特异性转录特征相关
影响因子：
16.6
作者：
Li J;Seidlitz J;Suckling J;Fan F;Ji GJ;Meng Y;Yang S;Wang K;Qiu J;Chen H;Liao W
通讯作者：
Liao W
影响因子：
4.3
作者：
Bu, Xuan;Yang, Chuang;Huang, Xiaoqi
通讯作者：
Huang, Xiaoqi
影响因子：
4.8
作者：
Li, Jiao;Biswal, Bharat B.;Liao, Wei
通讯作者：
Liao, Wei