Increased neutrophil motility by beta-glucan in the absence of chemoattractant.
Increased neutrophil motility by beta-glucan in the absence of chemoattractant.
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在没有化学引诱剂的情况下，β-葡聚糖可增加中性粒细胞的运动性。
DOI：
10.1097/00024382-200116060-00003
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
Reichner,J
中科院分区：
文献类型：
--
作者：
Harler,MB;Reichner,J
mdash;: Systemic candidasis is a life-threatening complication of antibiotic and immunosuppressive therapies and can alter host defense mechanisms through pathways that are poorly understood. Promotion of polymorphonuclear leukocyte (PMN) chemotaxis by [beta]-glucan towards fMLP or IL-8 gradients demonstrates a fundamental effect on host defenses by pathogenic fungi. The aim of the present study was to determine whether recognition of [beta]-glucan is sufficient to alter PMN motility in the absence of agonists of G-coupled protein chemotactic receptors. Present findings demonstrate a profound increase in PMN motility by [beta]-glucan supplementation of a fibronectin substratum in an underagarose migration assay. Motility on [beta]-glucan included a 3-fold increase in distance of migration, as well as a 5-fold increase in the number of PMNs recruited into the motile phase as compared to motility on fibronectin alone. This promotion of motility is determined by the [beta] 2 integrin complement receptor 3 (CR3)(CD11b/CD18) rather than the [beta] 1 integrin very late antigen 3 (VLA-3), which mediates chemotaxis on [beta]-glucan-supplemented matrix towards fMLP. PMN motility on [beta]-glucan-supplemented fibronectin was selectively decreased by inhibitors of pp60 src and ras, whereas motility was promoted by inhibition of p38-MAPK. No effect of these inhibitors was seen on PMNs migrating on fibronectin alone. Migration on [beta]-glucan-supplemented fibronectin, but not on fibronectin alone, was negatively regulated by protein kinase C (PKC) or cAMP activation. These findings indicate that [beta]-glucan is sufficient to alter the migratory capacity of PMN in the absence of costimulation by fMLP. Enhanced PMN migration on [beta]-glucan is mediated through specific integrins and second messenger pathways that are distinct from those utilized by PMNs migrating in the absence of [beta]-glucan.
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铜的溶血活性受螯合剂、白蛋白和铬的影响。
DOI：
10.1111/j.1600-0773.1984.tb01935.x
发表时间：
2009
期刊：
Acta pharmacologica et toxicologica
影响因子：
--
作者：
J. Aaseth;V. Skaug;J. Alexander
通讯作者：
J. Alexander
铜诱导的全血脂质过氧化和溶血：缺乏相关性的证据。
影响因子：
4.5
作者：
A. Piriou;C. Tallineau;S. Chahboun;R. Pontcharraud;O. Guillard
通讯作者：
O. Guillard
DOI：
--
发表时间：
1986
期刊：
影响因子：
--
作者：
Hultgren Bd;Menken Bz;Csallany As
通讯作者：
Csallany As
过氧化牛脑磷脂脂质体中丙二醛的测定。
影响因子：
2.9
作者：
J. Gutteridge
通讯作者：
J. Gutteridge
DOI：
10.1016/0020-711x(82)90050-7
发表时间：
1982-01-01
期刊：
INTERNATIONAL JOURNAL OF BIOCHEMISTRY
影响因子：
--
作者：
GUTTERIDGE, JMC
通讯作者：
GUTTERIDGE, JMC