Fruitless, doublesex and the genetics of social behavior in Drosophila melanogaster.
Fruitless, doublesex and the genetics of social behavior in Drosophila melanogaster.
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DOI：
10.1016/j.conb.2009.04.001
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发表时间：
2009-04
影响因子：
5.7
通讯作者：
Kravitz, Edward A.
中科院分区：
文献类型：
--
作者：
Siwicki, Kathleen K.;Kravitz, Edward A.
果蝇的两个转录因子fruitless和doubletex基因在调节果蝇社会行为的性二态模式中起着重要作用。一般认为，无结果的特定神经系统的发展和doubletex指定非神经组织的发展，最终声称，无结果是必要的，也是建立性别特异性行为模式的充分条件。然而，最近的几篇文章反驳了这一观点，证明至少，无结果和doubletex都参与了果蝇神经回路和行为的性二态特征的建立。
Two genes coding for transcription factors, fruitless and doublesex, have been suggested to play important roles in the regulation of sexually dimorphic patterns of social behavior in Drosophila melanogaster. The generalization that fruitless specified the development of the nervous system and doublesex specified non-neural tissues culminated with claims that fruitless was both necessary and sufficient to establish sex-specific patterns of behavior. Several recent articles refute this notion, however, demonstrating that at a minimum, both fruitless and doublesex are involved in establishing sexually dimorphic features of neural circuitry and behavior in fruit flies.
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