Association of diabetes mellitus and biochemical knee cartilage composition assessed by T(2) relaxation time measurements: Data from the osteoarthritis initiative.
Association of diabetes mellitus and biochemical knee cartilage composition assessed by T(2) relaxation time measurements: Data from the osteoarthritis initiative.
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DOI：
10.1002/jmri.25766
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发表时间：
2018-03
期刊：
影响因子：
--
通讯作者：
Link TM
中科院分区：
文献类型：
--
作者：
Chanchek N;Gersing AS;Schwaiger BJ;Nevitt MC;Neumann J;Joseph GB;Lane NE;Zarnowski J;Hofmann FC;Heilmeier U;McCulloch CE;Link TM
使用基于 MRI 的 T2 弛豫时间测量和膝关节结构异常来研究糖尿病 (DM) 的存在及其严重程度与关节软骨成分的关联。在骨关节炎倡议中，确定了 208 名患有 DM 的参与者（年龄 63.0±8.9 岁；111 名女性）和骨关节炎 (OA) 或轻度放射学胫股骨 OA（Kellgren-Lawrence (KL) 等级≤2）的危险因素，并与 208 名没有 DM 的对照者（年龄 63.3±9.1 岁；111 名女性）进行分组匹配。基线时患有糖尿病相关肾脏或眼科并发症或接受胰岛素治疗的受试者 (n=50) 被定义为严重 DM。对右膝的 3T MR 图像进行关节软骨 T2 评估，包括来自髌骨、股骨内侧和外侧以及胫骨的纹理和层流分析，以及使用修改后的 WORMS 的结构异常。聚类线性回归分析用于评估 DM 与 MRI 结果的关联。与对照组相比，DM 受试者的髌骨（平均差异 0.92ms [95% 置信区间 (CI) 0.79, 1.06]；P=0.001）和股骨内侧（平均差异 0.36ms [95% CI 0.27, 0.81]；P=0.006）软骨 T2 显着较高。所有区室的平均 DM 受试者显示出显着更高的纹理参数（方差，P=0.001；对比度，P=0.002；熵，P<0.001）。与对照组相比，严重 DM 受试者的胫骨内侧深层和浅层 T2 也更高（P=0.011 和 P=0.041）。各组间软骨、半月板及整体WORMS无显着差异（P>0.05）。与非糖尿病对照组相比，DM 受试者的软骨显示出更高且更异质的软骨 T2 值，表明关节软骨退化增加。这甚至影响了患有严重糖尿病的受试者的更多隔室。
To investigate the association of presence and severity of diabetes mellitus (DM) with articular cartilage composition, using MRI-based T2 relaxation time measurements, and structural knee abnormalities. In the Osteoarthritis Initiative 208 participants with DM (age 63.0±8.9y; 111 females) and risk factors for osteoarthritis (OA) or mild radiographic tibiofemoral OA (Kellgren-Lawrence (KL) grade≤2) were identified and group-matched with 208 controls without DM (age 63.3±9.1y; 111 females). Subjects with diabetes-related renal or ophthalmological complications or insulin treatment at baseline (n=50) were defined as severe DM. 3T MR images of the right knee were assessed for articular cartilage T2, including texture and laminar analyses derived from the patella, medial and lateral femur and tibia and for structural abnormalities using the modified WORMS. Clustered linear regression analyses were used to assess associations of DM with MRI findings. DM subjects had significantly higher cartilage T2 in the patella (mean difference 0.92ms [95% confidence interval (CI) 0.79, 1.06]; P=0.001) and medial femur (mean difference 0.36ms [95% CI 0.27, 0.81]; P=0.006) compared to controls. Averaged over all compartments DM subjects showed significantly higher texture parameters (variance, P=0.001; contrast, P=0.002; entropy, P<0.001). Subjects with severe DM additionally showed higher T2 in the medial tibial deep and superficial layers (P=0.011 and P=0.041) compared to controls. No significant differences in cartilage, meniscus and overall WORMS were found between the groups (P>0.05). In comparison to non-diabetic controls, cartilage in DM subjects showed a higher and more heterogeneous cartilage T2 values, indicating increased articular cartilage degeneration. This affected even more compartments in subjects with severe DM.
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影响因子：
4.7
作者：
Baum, Thomas;Joseph, Gabby B.;Arulanandan, Ahilan;Nardo, Lorenzo;Virayavanich, Warapat;Carballido-Gamio, Julio;Nevitt, Michael C.;Lynch, John;McCulloch, Charles E.;Link, Thomas M.
通讯作者：
Link, Thomas M.
影响因子：
4.4
作者：
Jungmann, Pia M.;Kraus, Mareen S.;Nardo, Lorenzo;Liebl, Hans;Alizai, Hamza;Joseph, Gabby B.;Liu, Felix;Lynch, John;McCulloch, Chuck E.;Nevitt, Michael C.;Link, Thomas M.
通讯作者：
Link, Thomas M.
影响因子：
4.9
作者：
Davies-Tuck, Miranda L.;Wang, Yuanyuan;Cicuttini, Flavia M.
通讯作者：
Cicuttini, Flavia M.
影响因子：
16.2
作者：
American Diabetes Association
通讯作者：
American Diabetes Association
影响因子：
3.3
作者：
Carballido-Gamio, Julio;Joseph, Gabby B.;Majumdar, Sharmila
通讯作者：
Majumdar, Sharmila