T(2) relaxation time measurements are limited in monitoring progression, once advanced cartilage defects at the knee occur: longitudinal data from the osteoarthritis initiative.
T(2) relaxation time measurements are limited in monitoring progression, once advanced cartilage defects at the knee occur: longitudinal data from the osteoarthritis initiative.
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DOI：
10.1002/jmri.24137
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发表时间：
2013-12
影响因子：
4.4
通讯作者：
Link, Thomas M.
中科院分区：
文献类型：
--
作者：
Jungmann, Pia M.;Kraus, Mareen S.;Nardo, Lorenzo;Liebl, Hans;Alizai, Hamza;Joseph, Gabby B.;Liu, Felix;Lynch, John;McCulloch, Chuck E.;Nevitt, Michael C.;Link, Thomas M.
研究膝关节软骨T2弛豫时间的自然演变与不同程度的形态软骨异常，评估骨关节炎倡议的3 T MRI。纳入了245例45-60岁无影像学OA患者的右膝MRI。在基线和2年随访时，对肱骨进行分段，并在5个隔室（髌骨、股骨内侧和外侧髁、胫骨内侧和外侧）中生成T2标测图。我们研究了T2值和T2值的两年变化与各种全器官MR成像评分（蠕虫）的相关性。用ANOVA和Students t检验进行统计分析。较高的基线T2与基线时更严重的软骨缺损和随后的软骨丢失相关（P<0.001）。然而，纵向T2变化与软骨缺损的基线（P=0.038）和随访（P=0.002）严重程度呈负相关。发生新软骨缺损的膝关节的T2增加幅度小于无缺损的受试者（P=0.045）。基线T2较高的个体显示T2随时间的增加较小（P<0.001）。纵向T2变化与基线T2值和形态软骨异常的负相关性表明，一旦发生形态软骨缺损，T2值可能会限制进一步评估软骨退化。
To study the natural evolution of cartilage T2 relaxation times in knees with various extents of morphological cartilage abnormalities, assessed with 3T MRI from the Osteoarthritis Initiative. Right knee MRIs of 245, 45–60 year old individuals without radiographic OA were included. Cartilage was segmented and T2 maps were generated in five compartments (patella, medial and lateral femoral condyle, medial and lateral tibia) at baseline and two-year follow-up. We examined the association of T2 values and two-year change of T2 values with various Whole-Organ MR Imaging Scores (WORMS). Statistical analysis was performed with ANOVA and Students t-tests. Higher baseline T2 was associated with more severe cartilage defects at baseline and subsequent cartilage loss (P<0.001). However, longitudinal T2 change was inversely associated with both baseline (P=0.038) and follow-up (P=0.002) severity of cartilage defects. Knees that developed new cartilage defects had smaller increases in T2 than subjects without defects (P=0.045). Individuals with higher baseline T2 showed smaller T2 increases over time (P<0.001). An inverse correlation of longitudinal T2 changes versus baseline T2 values and morphological cartilage abnormalities suggests that once morphological cartilage defects occur, T2 values may be limited for evaluating further cartilage degradation.
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影响因子：
4.7
作者：
Baum, Thomas;Joseph, Gabby B.;Arulanandan, Ahilan;Nardo, Lorenzo;Virayavanich, Warapat;Carballido-Gamio, Julio;Nevitt, Michael C.;Lynch, John;McCulloch, Charles E.;Link, Thomas M.
通讯作者：
Link, Thomas M.
影响因子：
7
作者：
Peterfy CG;Schneider E;Nevitt M
通讯作者：
Nevitt M
影响因子：
3.3
作者：
Li, Xiaojuan;Pai, Alex;Blumenkrantz, Gabrielle;Carballido-Gamio, Julio;Link, Thomas;Ma, Benjamin;Ries, Michael;Majumdar, Sharmila
通讯作者：
Majumdar, Sharmila
影响因子：
27.4
作者：
Hunter, D. J.;Niu, J. B.;Felson, D. T.
通讯作者：
Felson, D. T.
影响因子：
2.1
作者：
Stahl, Robert;Jain, Sapna K.;Lutz, Juergen;Wyman, Bradley T.;Le Graverand-Gastineau, Marie-Pierre Hellio;Vignon, Eric;Majumdar, Sharmila;Link, Thomas M.
通讯作者：
Link, Thomas M.