Golden carbon nanotubes as multimodal photoacoustic and photothermal high-contrast molecular agents.
Golden carbon nanotubes as multimodal photoacoustic and photothermal high-contrast molecular agents.
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DOI：
10.1038/nnano.2009.231
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发表时间：
2009-10
影响因子：
38.3
通讯作者：
中科院分区：
文献类型：
--
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碳纳米管已显示出作为肿瘤和感染的光声和光热成像的造影剂的前景，因为它们提供高分辨率并允许深层组织成像。然而，在体内的应用已被限制的相对较低的吸收显示的纳米管在近红外波长和对毒性的关注。在这里，我们表明，镀金的碳纳米管-称为金碳纳米管-可用作光声和光热造影剂，增强近红外对比度（~102倍），用于靶向小鼠淋巴管，使用极低的激光能量密度水平为几mJ cm−2。抗体结合的金色碳纳米管被用于绘制淋巴管内皮受体，初步的体外活性测试显示金色碳纳米管具有最小的毒性。这种新的纳米材料可能是现有纳米颗粒和荧光标记物的有效替代品，用于体内分子结构的非侵入性靶向成像。
Carbon nanotubes have shown promise as contrast agents for photoacoustic and photothermal imaging of tumours and infections because they offer high resolution and allow deep tissue imaging. However, in vivo applications have been limited by the relatively low absorption displayed by nanotubes at near-infrared wavelengths and concerns over toxicity. Here, we show that gold-plated carbon nanotubes—termed golden carbon nanotubes—can be used as photoacoustic and photothermal contrast agents with enhanced near-infrared contrast (~102-fold) for targeting lymphatic vessels in mice using extremely low laser fluence levels of a few mJ cm−2. Antibody-conjugated golden carbon nanotubes were used to map the lymphatic endothelial receptor, and preliminary in vitro viability tests show golden carbon nanotubes have minimal toxicity. This new nanomaterial could be an effective alternative to existing nanoparticles and fluorescent labels for non-invasive targeted imaging of molecular structures in vivo.
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影响因子：
3.7
作者：
Galanzha, Ekaterina I.;Shashkov, Evgeny V.;Tuchin, Valery V.;Zharov, Vladimir P.
通讯作者：
Zharov, Vladimir P.
影响因子：
2.4
作者：
Kim, Jin-Woo;Shashkov, Evgeny V.;Zharov, Vladimir P.
通讯作者：
Zharov, Vladimir P.
影响因子：
17.1
作者：
Jan, Edward;Byrne, Stephen J.;Kotov, Nicholas A.
通讯作者：
Kotov, Nicholas A.
DOI：
10.1073/pnas.2232479100
发表时间：
2003-11-11
影响因子：
11.1
作者：
Hirsch, LR;Stafford, RJ;West, JL
通讯作者：
West, JL
影响因子：
4
作者：
Kim, Jin-Woo;Kotagiri, Nalinikanth;Deaton, Russell
通讯作者：
Deaton, Russell