Pesticides, gene polymorphisms, and bladder cancer among Egyptian agricultural workers.
Pesticides, gene polymorphisms, and bladder cancer among Egyptian agricultural workers.
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DOI：
10.1080/19338244.2013.853646
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发表时间：
2015
影响因子：
1.8
通讯作者：
Loffredo CA
中科院分区：
文献类型：
--
作者：
Amr S;Dawson R;Saleh DA;Magder LS;St George DM;El-Daly M;Squibb K;Mikhail NN;Abdel-Hamid M;Khaled H;Loffredo CA
我们在埃及男性农业工人中研究了农药暴露、NAD(P)H：苯醌氧化还原酶I(NQO1)和超氧化物歧化酶2(SOD2)基因多态性与膀胱癌风险的关系。我们使用Logistic回归分析了一项多中心病例对照研究的数据，并估计了调整后的优势比(OR)和95%CI(可信区间)与膀胱癌风险增加(1.68(1.23-2.29))呈剂量依赖关系。在尿路上皮(1.79(1.25-2.56))比鳞状细胞癌(1.55(1.03-2.31))中，这种相关性略强；在低NQO1和高SOD2混合基因的参与者中(2.14(1.19-3.85))，与高NQO1和低SOD2基因的参与者(1.53(0.73-3.25)相比)。总而言之，在埃及的男性农业工人中，农药暴露与膀胱癌风险相关，可能受到基因多态的调节。
We examined the associations between pesticide exposure, genetic polymorphisms for NAD(P)H:quinone oxidoreductase I (NQO1) and superoxide dismutase 2 (SOD2), and urinary bladder cancer risk among male agricultural workers in Egypt. We used logistic regression to analyze data from a multi-center case-control study and estimate adjusted odds ratio (OR) and 95% CI (confidence interval) Exposure to pesticides was associated with increased bladder cancer risk (1.68 (1.23–2.29)) in a dose-dependent manner. The association was slightly stronger for urothelial (1.79 (1.25–2.56) than for squamous cell carcinoma (1.55 (1.03–2.31)), and among participants with combined genotypes for low NQO1 and high SOD2 (2.14 (1.19–3.85) activities as compared to those with high NQO1 and low SOD2 genotypes (1.53 (0.73–3.25)). In conclusion, among male agricultural workers in Egypt, pesticide exposure is associated with bladder cancer risk and possibly modulated by genetic polymorphism.
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