Parametric analysis of a novel semi-circular microfluidic CD-ELISA valve.
Parametric analysis of a novel semi-circular microfluidic CD-ELISA valve.
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DOI：
10.1186/1754-1611-5-15
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发表时间：
2011-11-07
影响因子：
5.6
通讯作者：
Lin SI
中科院分区：
文献类型：
--
作者：
Lin SI
CD-ELISA法利用微流控排序法和离心力来控制试液流入反应区。CD-ELISA最具挑战性的部分是对不同生物测试液的流动过程进行控制，即微流控通道阀门的控制顺序。因此，微流控通道阀是CD-ELISA最重要的流体通道结构。在这项研究中，我们提出了一种适用于大范围转速的阀门设计，可以应用于大批量生产(成型)。结合配套实验，采用基于两相流理论的数值模拟方法，验证了该新型阀门设计的可行性。研究了不同圆弧形状、距离d、半径r、圆心位置、接触角等对CD-EL ISA微流控通道阀设计的影响。从实验结果和模拟结果可以看出，最窄流道宽度和接触角是影响阀门爆裂频率的主要因素。这些都可以作为设计过程中的主要控制因素。
CD-ELISA uses the microfluidic ranking method and centrifugal force to control the testing solution as it flows into the reaction region. The most challenging part of CD-ELISA is controlling the flow process for different biological testing solutions, i.e. the controlling sequence for the microfluidic channel valves. The microfluidic channel valve is therefore the most important fluid channel structure for CD-ELISA. In this study, we propose a valve design suitable for a wide range rotational speeds which can be applied for mass production (molding). Together with supporting experiments, simulation based on two-phase flow theory is used in this study, and the feasibility of this novel valve design is confirmed. Influencing design factors for the microfluidic channel valves in CD-ELISA are investigated, including various shapes of the arc, distance d, radius r, the location of the center of the circle, and the contact angle. From both the experimental results and the simulated results, it is evident that the narrowest channel width and the contact angle are the primary factors influencing valve burst frequency. These can be used as the main controlling factors during the design.
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